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Cat. No.: HY-184961

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Anticancer agent 353

Anticancer agent 353 is a heterobifunctional antitumor agent with weak ERα inhibitory activity and anticancer activity. Anticancer agent 353 exhibits growth inhibitory activity against MCF7 cells. Anticancer agent 353 can be used in cancer research.

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CAS No.: 3099598-10-1
Formule: C₅₂H₅₈N₈OS
Masse moléculaire:843.13

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Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 353 Chemical Structure

CAS No.: 3099598-10-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

ERα

Voir tous les produits spécifiques à Isoform Estrogen Receptor/ERR :

In Vitro

Anticancer agent 353 (III-146) exhibits growth inhibitory activity against MCF7 cells, with a GI₅₀ of < 0.05 μM^[1].
Anticancer agent 353 exhibits activity in both Doxorubicin (HY-15142A)-induced ERα-overexpressing and non-induced T-Rex 293 cells, with consistent antiproliferative activity between the two groups (GI₅₀ = 0.5-2.5 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3099598-10-1
Masse moléculaire 843.13
Formule C₅₂H₅₈N₈OS
SMILES

OC1=CC=C([C@@H](C2=CC=C(N3CC(C3)CN4CCN(CC4)CC5CN(C6=CC=C(C7=N[C@H](C)C8=NN=C(C)N8C9=C7C(C)=C(C)S9)C=C6)C5)C=C2)[C@@H](C%10=CC=CC=C%10)CC%11)C%11=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Eastman KJ, et al. Heterobifunctional compounds and their use in treating disease. WO2025189056 A1. WIPO. 2025.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Anticancer agent 353

Voir tous les produits spécifiques à Isoform Estrogen Receptor/ERR