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Cat. No.: HY-173639

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AZD0516

Name: AZD0516
Brand: MedChemExpress
SKU: HY-173639
Price: 1140.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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AZD0516 is an antibody-drug conjugate (ADC) targeting STEAP2. It is formed by conjugating an anti-STEAP2 monoclonal antibody (mAb) via interchain cysteines to a maleimide-reactive, β-glucuronidase-cleavable linker (HY-173635) and the topoisomerase 1 inhibitor Exatecan (HY-13631). AZD0516 is applicable to the research of metastatic castration-resistant prostate cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99.15%
Masse moléculaire:162163 (average)

Stockage:

-80°C, protect from light

AZD0516 Chemical Structure

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- Essai clinique
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target^[1]^[2]^[3]^[4]

Topoisomerase I

Voir tous les produits spécifiques à Isoform Topoisomerase :

In Vitro

AZD0516 potently inhibits prostate cancer cell viability with low nanomolar IC₅₀ values, inducing DNA damage and apoptotic cell death^[1].
AZD0516 mediates bystander cell killing of STEAP2-negative cells in co-culture with STEAP2-positive cells via intracellular release of its Exatecan (HY-13631) payload^[1].
The anti-STEAP2 monoclonal antibody component of AZD0516 exhibits specific binding, rapid internalization, and efficient lysosomal trafficking in prostate cancer cells^[1].
The anti-STEAP2 monoclonal antibody component of AZD0516 binds specifically to human, cynomolgus monkey, mouse, and rat STEAP2, with no cross-reactivity to other STEAP family members^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

Appearance Liquid
Masse moléculaire 162163 (average)
Color Colorless to light yellow
SMILES

[AZD0516]
Livraison

Shipping with dry ice.
Stockage

-80°C, protect from light

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (281 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Monlish D, et al. Abstract 1158: Preclinical characterization of AZD0516, a novel STEAP2 antibody‑drug conjugate (ADC) for the treatment of prostate cancer. Cancer Research. 2025 Apr 15;85(8_Supplement_1):1158.

[2]. Ma Z, et al. Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2). Journal of medicinal chemistry. 2023 Aug 24;66(16):10991-11026. [Content Brief]

[3]. Dunne VL, et al. Synergistic Activity of DNA Damage Response Inhibitors in Combination with Radium-223 in Prostate Cancer. Cancers. 2024 Apr 15;16(8):1510.

[4]. Burrell PE. GRP94 is a novel ATM interactor and putative substrate which regulates oncogenic receptor expression and microglial activation [dissertation]. Durham (NC): Duke University; 2025 Sep 12.

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- Essai clinique
Chemical Information
Pureté et documentation
Références

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AZD0516

Anti-STEAP2 Antibody

Exatecan

Voir tous les produits spécifiques à Isoform Topoisomerase