Bakuchicin
Bakuchicin (Allopsoralen) is a compound that can be found in Psoralea corylifolia. It has certain inhibitory activity against topoisomerase II. In the cell model infected with Simian virus 40 (SV40), the IC50 of Bakuchicin against topoisomerase II is 404 μM. Bakuchicin can be used in the research of the anti-infection field.
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- CAS No.: 4412-93-5
- Formule: C11H6O3
- Masse moléculaire:186.16
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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Topoisomerase II 404 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HeLa | IC50 |
404 μM
Compound: 6
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Inhibition of DNA topoisomerase 2 in human HeLa cells by kinetoplast DNA decantation assay
Inhibition of DNA topoisomerase 2 in human HeLa cells by kinetoplast DNA decantation assay
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[PMID: 9544566] |
Chemical Information
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CAS No. 4412-93-5
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Masse moléculaire 186.16
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Formule C11H6O3
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SMILES
O=C1C=CC2=C(C=CC3=C2OC=C3)O1
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Synonyms
Allopsoralen
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bakuchicin Related Classifications
HY-N11698 Related Classifications
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