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Cat. No.: HY-184012

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BAY-163

BAY-163 is a tertiary urea derivative and inactive negative control probe for BAY-439 (HY-178123). BAY-163 does not inhibit phospholipase A2 group V (PLA2-G5) activity in immune cells. BAY-163 can be used for research on endometriosis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3134928-97-2
Formule: C₂₃H₂₈N₄O₂
Masse moléculaire:392.49

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BAY-163 Chemical Structure

CAS No.: 3134928-97-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
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Activité biologique

Description

IC₅₀ & Target^[1]

PLA2

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In Vitro

BAY-163 shows no inhibitory activity against human phospholipase A2 group V (hPLA2-G5) at concentrations up to 25 μM^[1].
BAY-163 does not bind to human phospholipase A2 group V (hPLA2-G5) at concentrations up to 10 μM^[1].
BAY-163 shows no inhibitory activity against rat phospholipase A₂ group V (rPLA₂-G5) at concentrations up to 20 μM^[1].
BAY-163 shows no inhibitory activity against human cytosolic phospholipase A₂ group IVA (hPLA₂-G4A) or human phospholipase A₂ group VII (hPLA₂-G7) at concentrations up to 20 μM^[1].
BAY-163 shows no inhibitory activity against human secretory phospholipase A2 group IIA (hPLA2-G2A) at concentrations up to 20 μM, and weak inhibitory activity against human secretory phospholipase A2 group X (hPLA2-G10) with an IC₅₀ of 14.3 μM^[1].
BAY-163 shows no inhibitory activity against phospholipase A2 group V (PLA2-G5) in THP-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3134928-97-2
Masse moléculaire 392.49
Formule C₂₃H₂₈N₄O₂
SMILES

O=C(N(C)C)N(CC1)CCC1OC2=CC=C(C#CC3=CC=NC(NCC)=C3)C=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Langer G, et al. Identification of the Piperidyl Urea Derivative BAY-439 as a Potent and Selective Inhibitor of Human Phospholipase A2 Group V (hPLA2-G5) for the Treatment of Inflammatory Pain. J Med Chem. 2026 May 19. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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BAY-163

Voir tous les produits spécifiques à Isoform Phospholipase