BP-1-108
BP-1-108 is a selective inhibitor of STAT5 (Ki=8.3 μM) with anticancer activity. BP-1-108 induces apoptosis of leukemia cells by inhibiting the phosphorylation of STAT5. BP-1-108 can be used in the study of acute myeloid leukemia and prostate cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1334492-85-1
- Formule: C32H38N2O6S
- Masse moléculaire:578.72
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
STAT5 8.3 μM (Ki) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
42 μM
Compound: BP-1-108
|
Cytotoxicity against human K562 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining
Cytotoxicity against human K562 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining
|
[PMID: 22148584] |
| MV4-11 | IC50 |
17 μM
Compound: BP-1-108
|
Cytotoxicity against human MV4-11 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining
Cytotoxicity against human MV4-11 cells expressing STAT5 after 48 hrs by alamar blue fluorescent staining
|
[PMID: 22148584] |
| NIH3T3 | IC50 |
100 μM
Compound: BP-1-108
|
Disruption of preformed STAT5 homodimer in NIH3T3 cells co-expressing human EGFR nuclear extracts by electrophoretic mobility shift assay
Disruption of preformed STAT5 homodimer in NIH3T3 cells co-expressing human EGFR nuclear extracts by electrophoretic mobility shift assay
|
[PMID: 22148584] |
Chemical Information
-
CAS No. 1334492-85-1
-
Masse moléculaire 578.72
-
Formule C32H38N2O6S
-
SMILES
O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(C)C=C(C)C=C4C)=O)=O)C=C1O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BP-1-108 Related Classifications
HY-125151 Related Classifications
Powered by Bioz