BRD4 ligand 2
BRD4 ligand 2 is a BRD4 BD1 inhibitor with an IC50 of 46.4 nM. BRD4 ligand 2 inhibits the proliferation of lymphoma cells. BRD4 ligand 2 also serves as a target protein ligand for PROTACs, and is used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131). BRD4 ligand 2 is applicable to research related to lymphoma.
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- CAS No.: 2133902-07-3
- Formule: C20H19N3O2
- Masse moléculaire:333.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
IC50 & Target
[1]|
BRD4 BD1 46.4 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CT26 | IC50 |
35.98 μM
Compound: 13
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Antiproliferative activity against human CT26 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human CT26 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
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[PMID: 33862375] |
| HCT-116 | IC50 |
3.341 μM
Compound: 14
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Antiproliferation activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferation activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 33214826] |
| HepG2 | IC50 |
18.77 μM
Compound: 13
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
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[PMID: 33862375] |
| THP-1 | IC50 |
3.26 μM
Compound: 6
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Antiproliferative activity against human THP1 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo assay
Antiproliferative activity against human THP1 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo assay
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[PMID: 31813613] |
| U-266 | IC50 |
35.35 μM
Compound: 13
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Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
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[PMID: 33862375] |
In Vitro
BRD4 ligand 2 (Compound 6) potently inhibits BRD4 BD1 in the AlphaScreen biochemical assay, with an IC50 value of 46.4 nM[1].
BRD4 ligand 2 (72 h) inhibits the proliferation of human monocytic lymphoma THP-1 cells, with an IC50 of 3.26 μM after 72 h of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2133902-07-3
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Masse moléculaire 333.38
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Formule C20H19N3O2
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SMILES
CC1=NOC(C)=C1C2=CC=C3C(C(NC(N3C)=O)C4=CC=CC=C4)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BRD4 ligand 2 Related Classifications
HY-150941 Related Classifications
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