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Cat. No.: HY-50692

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CAY10734

Name: CAY10734
Brand: MedChemExpress
SKU: HY-50692
Price: 122.00 USD
Availability: InStock
Rating: 5 (1 reviews)

CAY10734 is the agonist for sphingosine-1-phosphate receptor 1 (S1P1) with an IC₅₀ of 1.3 nM. CAY10734 promotes the recirculation of peripheral blood lymphocytes, and is a potential immunosuppressant.

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CAS No.: 635701-59-6
Formule: C₂₃H₂₅N₃O₃
Masse moléculaire:391.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

CAY10734 Chemical Structure

CAS No.: 635701-59-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform LPL Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.6 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 1 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 1 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	1 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 5 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 5 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	70 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	>10000 nM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 2 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 2 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	12 μM Compound: 26	Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 3 expressed in CHO cells Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 3 expressed in CHO cells	[PMID: 16190743]
CHO	IC₅₀	>10 μM Compound: 5	Displacement of [33P]S1P from human S1P2 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P2 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	0.6 nM Compound: 5	Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	1 nM Compound: 5	Displacement of [33P]S1P from human S1P5 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P5 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	70 nM Compound: 5	Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	12 μM Compound: 5	Displacement of [33P]S1P from human S1P3 receptor expressed in CHO cells Displacement of [33P]S1P from human S1P3 receptor expressed in CHO cells	[PMID: 16621543]
CHO	IC₅₀	0.6 nM Compound: C	Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranes Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranes	[PMID: 24900286]
CHO	IC₅₀	12 nM Compound: C	Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranes Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranes	[PMID: 24900286]

Chemical Information

CAS No. 635701-59-6
Masse moléculaire 391.46
Formule C₂₃H₂₅N₃O₃
SMILES

O=C(O)C1CN(C1)CC2=CC=C(C=C2)C3=NOC(C4=CC=C(CC(C)C)C=C4)=N3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li Z, et al., Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem. 2005 Oct 6;48(20):6169-73. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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