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Cat. No.: HY-164414

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CCT129254

(Synonyms: AT 11854)

CCT129254 is a potent Akt inhibitor. CCT129254 reduces the motility of melanoma cells in vivo.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 885500-12-9
Formule: C₁₉H₂₁ClN₆O
Masse moléculaire:384.86

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CCT129254 Chemical Structure

CAS No.: 885500-12-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

CCT129254 is a potent Akt inhibitor. CCT129254 reduces the motility of melanoma cells in vivo^[1].

Voir tous les produits spécifiques à Isoform Akt :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	5235 nM Compound: 3	Inhibition of human ERG expressed in CHO cells by ionworks assay Inhibition of human ERG expressed in CHO cells by ionworks assay	[PMID: 23394218]
MDA-MB-468	IC₅₀	328 nM Compound: 3	Inhibition of Akt in human MDA-MB-468 cells assessed as inhibition of GSK3beta phosphorylation after 2 hrs by laser scanning cytometry Inhibition of Akt in human MDA-MB-468 cells assessed as inhibition of GSK3beta phosphorylation after 2 hrs by laser scanning cytometry	[PMID: 23394218]
PC-3M	IC₅₀	>50 nM Compound: 21, CCT129524	Antiproliferative activity against human PC3M cells after 96 hrs by SRB assay Antiproliferative activity against human PC3M cells after 96 hrs by SRB assay	[PMID: 20151677]
U-87MG ATCC	GI₅₀	0.93 nM Compound: 21, CCT129524	Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISA Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISA	[PMID: 20151677]
U-87MG ATCC	IC₅₀	17 nM Compound: 21, CCT129524	Antiproliferative activity against human U87MG cells after 96 hrs by SRB assay Antiproliferative activity against human U87MG cells after 96 hrs by SRB assay	[PMID: 20151677]

Chemical Information

CAS No. 885500-12-9
Masse moléculaire 384.86
Formule C₁₉H₂₁ClN₆O
SMILES

ClC1=CC=C(CNC(C2(N)CCN(C3=NC=NC4=C3C=CN4)CC2)=O)C=C1
Synonyms

AT 11854
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Gandalovičová A, et al. Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges. Trends Cancer. 2017 Jun;3(6):391-406. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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CCT129254

Voir tous les produits spécifiques à Isoform Akt

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CCT129254 Related Classifications

HY-164414 Related Classifications