Citral
Based on 1 publication(s) in Google Scholar
Citral is an orally active monoterpene compound in lemon grass essential oil and a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines, and has analgesic, anti-injurious and anti-inflammatory effects[2][3].
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- Pureté: 99.81%
- CAS No.: 5392-40-5
- Formule: C10H16O
- Masse moléculaire:152.23
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Stockage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) Citral
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Activité biologique
Citral (10, 50, 100 μg/mL, 72 h) has no cytotoxicity to J774 macrophages[1]. Citral (0-0.5 μM, 72 h) inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 breast cancer cell line[2]. Citral (0-100 μg/mL, 72 h) exhibits anti-proliferative and pro-apoptotic activities in MDA-MB-231 breast cancer cell line[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:J774 cell
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Concentration:10, 50, 100 μg/mL
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Incubation Time:72 h
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Result:Didn't affect the cell viability of J774 cells
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Cell Line:MCF-7 cell
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Concentration:0-0.5 μM
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Incubation Time:72 h
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Result:Inhibited the proliferation of MCF-7 cells
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Cell Line:MDA-MB-231 cell
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Concentration:0-100 μg/mL
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Incubation Time:72 h
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Result:Inhibited the cell viability of MDA-MB-231 cells
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:pleurisy adult (2 to 3 months old) male Swiss mice[1].
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Dosage:100 mg / kg body weight
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Administration:oral gavage (p.o.)
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Result:Reduced white blood cell count and TNF-α expression level [1].
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Animal Model:Female BALB/c mice[4].
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Dosage:10, 20, 40 mg/kg body weight
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Administration:intraperitoneal injection (i.p.)
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Result:Attenuated uterine pathological damage, infammation, and ferroptosis[4].
Chemical Information
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CAS No. 5392-40-5
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Appearance Liquid (Density: 0.888 g/cm3)
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Masse moléculaire 152.23
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Formule C10H16O
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Color Colorless to light yellow
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SMILES
C/C(C)=C\CC/C(C)=C/C=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Bioeng Transl Med
An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae/butyrate/retinoic acid axis. [Abstract]2021 Apr 2;6(3):e10219. PMID: 34589596
Solvant et solubilité
DMSO : 100 mg/mL (656.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Campos CA, et al. Anti-hyperalgesic and anti-inflammatory effects of citral with β-cyclodextrin and hydroxypropyl-β-cyclodextrin inclusion complexes in animal models. Life Sci. 2019 Jul 15;229:139-148. [Content Brief]
[2]. Chaouki W, et al. Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells. Fundam Clin Pharmacol. 2009 Oct;23(5):549-56. [Content Brief]
[3]. Souza ACS, et al. Citral presents cytotoxic and genotoxic effects in human cultured cells. Drug Chem Toxicol. 2020 Jul;43(4):435-440. [Content Brief]
[4]. Zhao W, et al. Citral protects against LPS-induced endometritis by inhibiting ferroptosis through activating Nrf2 signaling pathway. Inflammopharmacology. 2023 Jun;31(3):1551-1558. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.5690 mL | 32.8450 mL | 65.6901 mL | 164.2252 mL |
| 5 mM | 1.3138 mL | 6.5690 mL | 13.1380 mL | 32.8450 mL | |
| 10 mM | 0.6569 mL | 3.2845 mL | 6.5690 mL | 16.4225 mL | |
| 15 mM | 0.4379 mL | 2.1897 mL | 4.3793 mL | 10.9483 mL | |
| 20 mM | 0.3285 mL | 1.6423 mL | 3.2845 mL | 8.2113 mL | |
| 25 mM | 0.2628 mL | 1.3138 mL | 2.6276 mL | 6.5690 mL | |
| 30 mM | 0.2190 mL | 1.0948 mL | 2.1897 mL | 5.4742 mL | |
| 40 mM | 0.1642 mL | 0.8211 mL | 1.6423 mL | 4.1056 mL | |
| 50 mM | 0.1314 mL | 0.6569 mL | 1.3138 mL | 3.2845 mL | |
| 60 mM | 0.1095 mL | 0.5474 mL | 1.0948 mL | 2.7371 mL | |
| 80 mM | 0.0821 mL | 0.4106 mL | 0.8211 mL | 2.0528 mL | |
| 100 mM | 0.0657 mL | 0.3285 mL | 0.6569 mL | 1.6423 mL |
Citral Related Classifications
HY-N7083 Related Classifications
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