CMP-Sialic acid
Based on 3 publication(s) in Google Scholar
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates.
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- CAS No.: 3063-71-6
- Formule: C20H31N4O16P
- Masse moléculaire:614.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Références
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Publications Citing Use of MedChemExpress (MCE) CMP-Sialic acid
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Activité biologique
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Human Endogenous Metabolite |
CMP-Sialic acid (22.5 μM, 45 min) can be used as a CMAH substrate to detect the formation of Neu5Gc in platelet lysates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3063-71-6
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Masse moléculaire 614.45
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Formule C20H31N4O16P
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SMILES
O[C@@H]1[C@H](O[C@@H](N2C(N=C(N)C=C2)=O)[C@@H]1O)COP(O[C@@]3(O[C@@]([C@H](NC(C)=O)[C@@H](O)C3)([H])[C@H](O)[C@H](O)CO)C(O)=O)(O)=O
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Synonyms
CMP-Neu5Ac
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Adv Mater
Shutting Down the 'Language Encoder': A Pathogen-Derived Nano-Interferer Disrupt Sialylation Metabolism and Reprogram Intercellular Communication in Glioblastoma. [Abstract]2025 Nov 29:e16608. PMID: 41316829 -
Cell Host Microbe
Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism. [Abstract]2025 Jul 9;33(7):1133-1145.e4. PMID: 40494348
CMP-Sialic acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]
CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 d), the product of CMAS, enhanced gonococcal burden in C57BL/6 J WT and Ifnε−/− mice when administered intravaginally.
CMP-Sialic acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]
Intravaginal CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 days) instillation restored LOS sialylation in Ifnε−/− and anti-IFNAR-treated mice.
Pureté et documentation
Références
[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5. [Content Brief]
[3]. Mercado CP, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30;3:2795. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CMP-Sialic acid Related Classifications
HY-112942 Related Classifications
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