Conimine TFA
Based on 1 Customer Validation
Conimine TFA is a steroidal alkaloid, antibacterial agent and potentiator. Conimine TFA is isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Conimine TFA exhibits intrinsic antibacterial activity against methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. When combined with Penicillin, Conimine TFA shows synergistic antibacterial effects against methicillin-resistant Staphylococcus aureus; when combined with Vancomycin (HY-B0671), it exerts synergistic antibacterial effects against both methicillin-sensitive and methicillin-resistant Staphylococcus aureus.
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- Formule: C24H37F3N2O2
- Masse moléculaire:442.56
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Stockage:
4°C, stored under argon
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Conimine (two-fold serial dilutions; 24 h) TFA inhibits the growth of methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) with an MIC of 128 μg·mL−1 for both strains[1].
Conimine (1/64-1 of its MIC (128 μg·mL-1)) TFA exhibits synergistic antibacterial activity with penicillin against methicillin-resistant Staphylococcus aureus (MRSA) and with vancomycin against both methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA), while showing a nonrelative effect with penicillin against MSSA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Masse moléculaire 442.56
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Formule C24H37F3N2O2
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Color White to off-white
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SMILES
C[C@H]1[C@]2([H])[C@]3(CN1)[C@](CC2)([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)NC)=CC4)C)([H])CC3.OC(C(F)(F)F)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under argon
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Conimine TFA Related Classifications
HY-N15435A Related Classifications
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