COX-2-IN-48
COX-2-IN-48 (5-25), a COX-2 inhibitor with an IC50 of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.
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- Formule: C25H17ClF3NO2
- Masse moléculaire:455.86
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Human COX-2 51.7 nM (IC50) |
NF-κB p65 |
iNOS |
Chemical Information
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Masse moléculaire 455.86
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Formule C25H17ClF3NO2
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SMILES
FC(C1=C(C2=CC=C(Cl)C=C2)C(C3=CNC4=C3C=CC=C4)C5=C(O1)C=CC(OC)=C5)(F)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2-IN-48 Related Classifications
HY-168070 Related Classifications
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