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Cat. No.: HY-182626

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CS1P1

CS1P1 is a brain-penetrant and selective S1PR1 antagonist and PET radiotracer, with human S1PR1 IC₅₀ values of 2.1 nM. CS1P1 binds specifically to S1PR1 to enable in vivo receptor expression quantification. CS1P1 can be used as PET radiotracer when labelled with 11C. CS1P1 can be used for the research of multiple sclerosis, neointimal hyperplasia, vascular inflammation.

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CAS No.: 1246526-29-3
Formule: C₂₇H₂₃F₄N₃O₃
Masse moléculaire:513.48

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CS1P1 Chemical Structure

CAS No.: 1246526-29-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target^[1]

S1PR1

2.1 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform LPL Receptor :

In Vitro

CS1P1 (2 h) potently binds to recombinant human S1PR1 with an IC₅₀ of 2.1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CS1P1 (0.3 mg/kg; i.v.; single bolus) is well tolerated in male and female Sprague Dawley rats, with no observable adverse effects identified over 15 days^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male and female)^[2]
Dosage:

0.3 mg/kg
Administration:

i.v.; single bolus
Result:

Allowed all rats to survive to scheduled euthanasia.
Caused no CS1P1-related effects on body weights, hematology parameters, clinical chemistry parameters, organ weights, or gross pathology findings at either Day 2 or Day 15.
Showed no CS1P1-related histopathology.

Chemical Information

CAS No. 1246526-29-3
Masse moléculaire 513.48
Formule C₂₇H₂₃F₄N₃O₃
SMILES

O=C(CCN(CC1=C(F)C=C(C2=NOC(C3=CC(C(F)(F)F)=C(C4=C(C)C=CC=C4)C=C3)=N2)C=C1)C)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Qiu L, et al. Discovery of a Promising Fluorine-18 Positron Emission Tomography Radiotracer for Imaging Sphingosine-1-Phosphate Receptor 1 in the Brain. J Med Chem. 2023;66(7):4671-4688. [Content Brief]

[2]. Liu H, et al. Acute Rodent Tolerability, Toxicity, and Radiation Dosimetry Estimates of the S1P1-Specific Radioligand [11C]CS1P1. Mol Imaging Biol. 2020;22(2):285-292. [Content Brief]

[3]. Castelo GP, et al. Pharmacological characterization of the CS1P1 compound as a S1P1 receptor antagonist. Ibro Neurosci Rep. 2023 Oct;15:S473-S474.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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CS1P1

Voir tous les produits spécifiques à Isoform LPL Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CS1P1 Related Classifications

HY-182626 Related Classifications