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CV-4-26

CV-4-26 (Compound 22) is a covalent inhibitor of TEAD. CV-4-26 inhibits YAP/TEAD-based transcription, leading to the reduction of CTGF and CYR61 expression. CV-4-26 inhibits Huh7 and HepG2 cell colony formation, induces cell cycle arrest, and apoptosis. CV-4-26 shows antitumor activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB).

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  • Formule: C18H12Cl2F3NO2
  • Masse moléculaire:402.19
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • CV-4-26 Chemical Structure
    CV-4-26 Chemical Structure
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