DHPS-IN-2
DHPS-IN-2 is an allosteric deoxyhypusine synthase (DHPS) inhibitor with an IC50 of 70 nM and a Kd of 26.4 μM. DHPS-IN-2 significantly suppresses melanoma cell migration and invasiveness in vitro and exhibits potent anti-tumor efficacy in an A375 cell zebrafish xenograft model. DHPS-IN-2 can be used for the study of melanoma.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C17H15IN2O2
- Masse moléculaire:406.22
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis
More
Activité biologique
DHPS-IN-2 (Compound 7C16) inhibits A375 and B16 cell proliferation with IC50 of 4.0 and 14.4 μM, and has a low cytotoxicity towards normal HaCaT cells (CC50 = 16.6 μM)[1].
DHPS-IN-2 (1-10 μM) significantly inhibits the invasion and migration abilities of A375 cells[1].
DHPS-IN-2 (1-10 μM, 24 h) inhibits melanoma proliferation by modulating the expression of melanoma-associated proteins (elF5A-Hyp) in A375 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:A375 cells
-
Concentration:1, 5 and 10 μM
-
Incubation Time:24 h
-
Result:Significantly reduced the level of eIF5A-Hyp.
Reduced the melanoma markers GP-100 and tyrosinase.
Did not affect the total expression of DHPS protein.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:A375 cells were fluorescently labeled with CM-DiI and Xenograft via microinjection into the yolk sac of 2 dpf wild-type AB strain zebrafish[1]
-
Dosage:15.6 μM
-
Administration:7 days
-
Result:Exhibited superior antitumor efficacy at lower concentrations.
Chemical Information
-
Masse moléculaire 406.22
-
Formule C17H15IN2O2
-
SMILES
IC1=CC=C(C=C1)CC2=NN=C(CC3=CC=CC=C3OC)O2
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DHPS-IN-2 Related Classifications
HY-175828 Related Classifications
Powered by Bioz