DS69910557
Based on 1 Customer Validation
DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.86%
- CAS No.: 3032750-17-4
- Formule: C32H33Cl2FN4O3
- Masse moléculaire:611.53
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
IC50: 0.08 μM (PTHR1)[1].
DS69910557 (compound 19e) has highly potent antagonistic activity for PTHR1 with an IC50 value of 0.08 μM[1].
DS69910557 (3 μM) exhibits excellent selectivity against human ether-a-go-go-related-gene (hERG) channel[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:5mg/kg
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Administration:PO
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Result:Showed excellent PK profile, high maximum plasma concentration and plasma exposure in rats.
Chemical Information
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CAS No. 3032750-17-4
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Appearance Solid
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Masse moléculaire 611.53
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Formule C32H33Cl2FN4O3
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Color Off-white to light yellow
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SMILES
ClC(C=N1)=CC(C2=C(C=C(Cl)C=C2)N3C4=CC=C(N5CC(F)(CN[C@@H]6CC[C@@H](C(O)=O)CC6)C5)C=C4)=C1C(C)(C)C3=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (163.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6352 mL | 8.1762 mL | 16.3524 mL | 40.8811 mL |
| 5 mM | 0.3270 mL | 1.6352 mL | 3.2705 mL | 8.1762 mL | |
| 10 mM | 0.1635 mL | 0.8176 mL | 1.6352 mL | 4.0881 mL | |
| 15 mM | 0.1090 mL | 0.5451 mL | 1.0902 mL | 2.7254 mL | |
| 20 mM | 0.0818 mL | 0.4088 mL | 0.8176 mL | 2.0441 mL | |
| 25 mM | 0.0654 mL | 0.3270 mL | 0.6541 mL | 1.6352 mL | |
| 30 mM | 0.0545 mL | 0.2725 mL | 0.5451 mL | 1.3627 mL | |
| 40 mM | 0.0409 mL | 0.2044 mL | 0.4088 mL | 1.0220 mL | |
| 50 mM | 0.0327 mL | 0.1635 mL | 0.3270 mL | 0.8176 mL | |
| 60 mM | 0.0273 mL | 0.1363 mL | 0.2725 mL | 0.6814 mL | |
| 80 mM | 0.0204 mL | 0.1022 mL | 0.2044 mL | 0.5110 mL | |
| 100 mM | 0.0164 mL | 0.0818 mL | 0.1635 mL | 0.4088 mL |
DS69910557 Related Classifications
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