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Cat. No.: HY-184150

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EN10

EN10 is a ligand for the muscle-specific E3 ligase KLHL41, which can be used to synthesize PROTAC KBD-1 (HY-184151) targeting BRD4.

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CAS No.: 2093466-80-7
Formule: C₂₁H₂₃N₃O
Masse moléculaire:333.43

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Please store the product under the recommended conditions in the Certificate of Analysis.

EN10 Chemical Structure

CAS No.: 2093466-80-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

EN10 is a ligand for the muscle-specific E3 ligase KLHL41, which can be used to synthesize PROTAC KBD-1 (HY-184151) targeting BRD4^[1].

IC₅₀ & Target^[1]

KLHL41

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase :

In Vitro

EN10 (5-15 μM; 30 min) selectively binds to KLHL41 (but not KLHL40) in live RH30 human muscle rhabdomyosarcoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2093466-80-7
Masse moléculaire 333.43
Formule C₂₁H₂₃N₃O
SMILES

[C@@H]1(C2=CC=CC=C2)OCC[C@H]1CNCC3=CNN=C3C4=CC=CC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Yim J, et al. Discovery of a KLHL41 Ligand for Muscle Specific Protein Degradation. Nat Commun. 2026;17(1):4551. Published 2026 May 26. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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EN10

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase