Endocrocin
Endocrocin is an anthraquinone fungal secondary metabolite. Endocrocin inhibits the recruitment and migration of neutrophils, and enhances the pathogenicity and virulence of Fumagillin (HY-B0751) in Drosophila. Endocrocin can be used in research related to invasive aspergillosis, viral infections and liver diseases.
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- CAS No.: 481-70-9
- Formule: C16H10O7
- Masse moléculaire:314.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
Endocrocin (10 nM-10 μM; 45 min) inhibits the chemotaxis of human primary neutrophils toward fMLP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3 days post-fertilization larvae[1]
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Dosage:10 μM
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Administration:bath incubation; 1 hour pre-treatment
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Result:Reduced the number of neutrophils recruited to the ventral fin compared to DMSO control.
Showed no reduction in zebrafish survival after 4 days at concentrations up to 10 μM.
Chemical Information
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CAS No. 481-70-9
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Masse moléculaire 314.25
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Formule C16H10O7
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SMILES
O=C(C(C(O)=C1C2=O)=C(C)C=C1C(C3=C2C(O)=CC(O)=C3)=O)O
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Structure Classification
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Initial Source
Aspergillus fumigatus
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Berthier E, et al. Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS pathogens. 2013;9(4):e1003289. [Content Brief]
[2]. Lim FY, et al. Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus. Applied and environmental microbiology. 2012 Jun;78(12):4117-25. [Content Brief]
[4]. Throckmorton K, et al. Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in Aspergillus fumigatus. Environmental microbiology. 2016 Jan;18(1):246-59. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Endocrocin Related Classifications
HY-N8541 Related Classifications
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