ER 50891
Based on 1 Customer Validation
ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis.
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- Pureté: 98.59%
- CAS No.: 187400-85-7
- Formule: C29H24N2O2
- Masse moléculaire:432.51
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Transcription Factor-Targeted Library
HY-L090
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Protein-protein Interaction Inhibitor Library
HY-L109
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Nuclear Receptor Compound Library
HY-L126
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Osteogenesis Compound Library
HY-L131
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Heterocyclic Compound Library
HY-L138
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Metabolic Enzyme Compound Library
HY-L146
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Activité biologique
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RXR α |
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Cell Line
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Type | Value | Description | References |
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| HL-60 | IC50 |
6.4 nM
Compound: 12f
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Antagonistic activity was evaluated in terms of inhibition of HL-60 cell differentiation activity by ATRA (10 nM)
Antagonistic activity was evaluated in terms of inhibition of HL-60 cell differentiation activity by ATRA (10 nM)
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[PMID: 11354380] |
ER 50891 (1-3 μM, 3 days) significantly promotes total cell metabolic activity of MC3T3-E1 preosteoblasts alone and antagonizes the inhibitory effect of ATRA on total cell metabolic activity[1].
ER 50891 (0.25-3 μM, 3 days) dose-dependently relieves the inhibition of 1 μM ATRA on OCN expression in MC3T3-E1 preosteoblasts[1].
ER 50891 (1.5-3 μM, 19 days) rescues the extracellular matrix mineralization of MC3T3-E1 preosteoblasts inhibited by ATRA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 187400-85-7
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Appearance Solid
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Masse moléculaire 432.51
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Formule C29H24N2O2
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Color Light yellow to yellow
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SMILES
O=C(O)C1=CC=C(C2=CC=C(C3=NC4=C(C(C)C)C=CC=C4C(C5=CC=CC=C5)=C3)N2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ER 50891 Related Classifications
HY-108531 Related Classifications
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