Ethonafide
Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β.
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- CAS No.: 160554-87-0
- Formule: C22H22N2O3
- Masse moléculaire:362.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.9 nM
Compound: 24
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Tested against A549 lung carcinoma in the sulforhodamine B assay.
Tested against A549 lung carcinoma in the sulforhodamine B assay.
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[PMID: 8648600] |
| L1210 | IC50 |
6.7 nM
Compound: 24
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Inhibitory activity against resistant murine leukemia L1210 cell lines.
Inhibitory activity against resistant murine leukemia L1210 cell lines.
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[PMID: 8648600] |
| L1210 | IC50 |
8 nM
Compound: 24
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Inhibitory activity against sensitive L1210 cell lines
Inhibitory activity against sensitive L1210 cell lines
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[PMID: 8648600] |
| L1210 | IC50 |
9.3 nM
Compound: 24
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An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line.
An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line.
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[PMID: 8648600] |
| MCF7 | IC50 |
11 nM
Compound: 24
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Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.
Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.
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[PMID: 8648600] |
| MCF7 | IC50 |
14 nM
Compound: 24
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Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay.
Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay.
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[PMID: 8648600] |
| MCF7 | IC50 |
18 nM
Compound: 24
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Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay.
Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay.
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[PMID: 8648600] |
| OVCAR-3 | IC50 |
0.8 nM
Compound: 24
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Inhibitory activity against OVCAR-3 cell line
Inhibitory activity against OVCAR-3 cell line
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[PMID: 8648600] |
| UACC-375 | IC50 |
19 nM
Compound: 24
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Inhibitory activity against AUC375 cell line
Inhibitory activity against AUC375 cell line
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[PMID: 8648600] |
| WiDr | IC50 |
17 nM
Compound: 24
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Tested against WiDr colon (sensitive) in the sulforhodamine B assay.
Tested against WiDr colon (sensitive) in the sulforhodamine B assay.
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[PMID: 8648600] |
| WiDr | IC50 |
63 nM
Compound: 24
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Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay.
Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay.
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[PMID: 8648600] |
Chemical Information
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CAS No. 160554-87-0
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Masse moléculaire 362.42
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Formule C22H22N2O3
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SMILES
O=C1N(CCN(C)C)C(C2=CC=C(OCC)C3=CC4=CC=CC=C4C1=C23)=O
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Synonyms
AMP-53; 6-Ethoxyazonafide
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Alan Pourpak, et al. Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells. J Pharmacol Exp Ther. 2007 Jun;321(3):1109-17. [Content Brief]
[2]. S M Sami, et al. 6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships. J Med Chem. 1996 Apr 12;39(8):1609-18. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ethonafide Related Classifications
HY-117543 Related Classifications
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