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Cat. No.: HY-W019824

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Farnesylacetone

Farnesylacetone acts as a transcriptional regulator, RNA synthesis modulator, and male hormone. Farnesylacetone can be extracted from the androgenic glands of the green crab (Carcinus maenas). Farnesylacetone modulates transcriptional processes, inhibits uridine incorporation into all types of RNA and leucine incorporation into ovaries, while stimulating uridine incorporation into tRNA/poly (A)⁺ RNA and leucine incorporation into testes. It suppresses electron transport in mitochondrial Complex I and Complex II. Farnesylacetone inhibits vitellogenesis in crustacean ovaries and stimulates uridine incorporation in crustacean intestines. It functions as an androgen in crustaceans.

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CAS No.: 762-29-8
Formule: C₁₈H₃₀O
Masse moléculaire:262.44

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Farnesylacetone Chemical Structure

CAS No.: 762-29-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

In Vitro

Protein/Amino Acid MetabolismNucleotide MetabolismMitochondrial FunctionMitochondrial Oxidative Phosphorylation

Protein/Amino Acid Metabolism

Nucleotide Metabolism

Farnesylacetone (100 nM; 1-3 h) inhibits protein and RNA synthesis in immature and mature ovaries of Carcinus maenas, promotes protein and RNA synthesis in testes of Carcinus maenas, and exerts its effects at the transcriptional level rather than directly acting on the translation process^[1].

Nucleotide Metabolism

Farnesylacetone (20 ng/mL; 3 h) stimulates RNA synthesis in the intestine of Carcinus maenas (shore crab), and exhibits organ specificity, as it only inhibits RNA synthesis in the ovary^[1].

Mitochondrial Function

Mitochondrial Oxidative Phosphorylation

Farnesylacetone (228 μM) inhibits electron transfer through Complex I (NADH ubiquinone reductase) and Complex II (succinate ubiquinone reductase) in isolated rat liver mitochondria, but does not inhibit electron transfer through Complex IV (cytochrome c oxidase); among these, succinate-driven electron transfer is more sensitive to it than NADH-driven electron transfer^[2].
Farnesylacetone (228-380 μM) specifically inhibits electron transfer between succinate dehydrogenase within Complex II and the ubiquinone pool in isolated rat liver mitochondria, with no inhibitory effect on succinate dehydrogenase itself; 380 μM Farnesylacetone reduces Complex II activity by 68.5% while increasing succinate dehydrogenase activity by 8%^[2].

Mitochondrial Oxidative Phosphorylation

Farnesylacetone (1 mM) neither inhibits the oxidation of DQH₂ nor the reduction of DQ in a cell-free system; instead, it stimulates electron transfer from the NADH + DQ conjugate to cytochrome c^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Endocrine Diseases

Chemical Information

CAS No. 762-29-8
Masse moléculaire 262.44
Formule C₁₈H₃₀O
SMILES

O=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Animal
Crustacea
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Berreur-Bonnenfant J, et al. Comparative effect of farnesylacetone on macromolecular synthesis in gonads of crustaceans. General and comparative endocrinology. 1984 Jun;54(3):462-8. [Content Brief]

[2]. Dupont J, et al. Farnesylacetone, a sesquiterpenic hormone of Crustacea, inhibits electron transport in isolated rat liver mitochondria. Biology of the cell. 1989;67(2):141-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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