Ttk - Ttk protein kinase Gene

Also Known as PYT; esk; Esk1; Mps1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22137

Summary

Enables identical protein binding activity; kinetochore binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in mitotic spindle assembly checkpoint signaling. Acts upstream of or within several processes, including meiotic spindle assembly checkpoint signaling; protein localization to organelle; and protein phosphorylation. Located in kinetochore. Is expressed in brain; lung; metanephros; and ureteric tip. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ttk Products (3)

mRNA Protein Name
NM_001110265.2 NP_001103735.1 dual specificity protein kinase TTK isoform 2
NM_001284272.2 NP_001271201.1 dual specificity protein kinase TTK isoform 3
NM_009445.3 NP_033471.2 dual specificity protein kinase TTK isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
21558374 MGI
enables kinetochore binding IMP
IMP: Inferred from mutant phenotype
25197064 MGI
enables protein serine/threonine/tyrosine kinase activity IDA
IDA: Inferred from direct assay
1375325 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within female meiosis chromosome segregation IMP
IMP: Inferred from mutant phenotype
21558374 MGI
acts upstream of or within meiotic prometaphase I IMP
IMP: Inferred from mutant phenotype
21558374 MGI
acts upstream of or within meiotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
21558374 MGI
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
25197064 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
1375325 MGI
acts upstream of or within peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
1375325 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
1375325 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
1375325 MGI
acts upstream of or within protein localization to chromosome IMP
IMP: Inferred from mutant phenotype
21558374 MGI
acts upstream of or within protein localization to kinetochore IMP
IMP: Inferred from mutant phenotype
21558374 MGI
acts upstream of or within protein localization to meiotic spindle midzone IMP
IMP: Inferred from mutant phenotype
21558374 MGI
acts upstream of or within spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
32284991 MGI
Cellular Component GO Annotation Evidence Références Source
located in kinetochore IDA
IDA: Inferred from direct assay
21558374 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity protein kinase TTK

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-101340 Luvixasertib Inhibitor 99.9600% Phase 2
HY-143904 PROTAC TTK degrader-1 Degrader 98.01% Phase 2

Pre-clinical Phase

Bioactive Molecules (28)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-116673 TTK21 Activator 99.39% Unkown
HY-14710 AZ3146 Inhibitor 99.42% Unkown
HY-101340A Luvixasertib hydrochloride Inhibitor 99.63% Unkown
HY-108709 CC-671 Inhibitor 99.06% Unkown
HY-171770 dAurAB5 99.03% Unkown
HY-168543 PROTAC AURKA degrader 3 Degrader 99.78% Unkown
HY-19544 JAK3-IN-1 Inhibitor 99.31% Unkown
HY-100024 NTRC 0066-0 Inhibitor 99.02% Unkown
HY-149213 LSD1/TLK1-IN-1 99.20% Unkown
HY-168540 PROTAC MPS1 degrader 1 99.90% Unkown
HY-168542 TTK ligand 2 Ligand 99.43% Unkown
HY-168545 SF-1 Ligand 99.50% Unkown
HY-144308 RMS-07 Inhibitor / Unkown
HY-132884 TTK inhibitor 3 Inhibitor / Unkown
HY-110347 Mps1-IN-1 dihydrochloride Inhibitor / Unkown
HY-116190 CFI-401870 Inhibitor / Unkown
HY-123675 CFI-400936 Inhibitor / Unkown
HY-143905 PROTAC TTK degrader-2 Degrader / Unkown
HY-160419 Mps1-IN-8 Inhibitor / Unkown
HY-162156 TTK inhibitor 4 Inhibitor / Unkown
HY-164955 TTK/PLK1-IN-1 Inhibitor / Unkown
HY-179430 TTK-IN-5 Inhibitor / Unkown
HY-182928 LRRK2-IN-21 Inhibitor / Unkown
HY-RS15226 TTK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116470 Mps1/TTK-IN-1 Inhibitor / Unkown
HY-RS16792 Ttk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21071 Ttbk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23232 Ttk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ttk NCBI NCBI:7272