BMX - BMX non-receptor tyrosine kinase Gene

Also Known as ETK; PSCTK2; PSCTK3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 660

About BMX

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,500,807-15,556,519 (from NCBI)

This gene has 5 transcripts (splice variants), 137 orthologues and 32 paralogues. Broad expression in bone marrow (RPKM 2.4), placenta (RPKM 2.2) and 21 other tissues.

Summary

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the STAT pathway, and regulates differentiation and tumorigenicity of several types of Cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

BMX Products (4)

mRNA Protein Name
NM_203281.3 NP_975010.1 cytoplasmic tyrosine-protein kinase BMX isoform 1
NM_001320866.2 NP_001307795.1 cytoplasmic tyrosine-protein kinase BMX isoform 2
XM_017029752.3 XP_016885241.1 cytoplasmic tyrosine-protein kinase BMX isoform X1
NM_001721.7 NP_001712.1 cytoplasmic tyrosine-protein kinase BMX isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
10688651 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10688651 GOA
Biological Process GO Annotation Evidence Références Source
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
11331870 GOA
involved in signal transduction IDA
IDA: Inferred from direct assay
10688651 GOA
Cellular Component GO Annotation Evidence Références Source
located in ruffle membrane IDA
IDA: Inferred from direct assay
11331870 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMX Protein Structure

PH

PH: PH domain (6 - 110)

BTK

BTK: BTK motif (119 - 148)

SH2

SH2: SH2 domain (296 - 377)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (417 - 665)

  • 0
  • 200
  • 400
  • 600
  • 675 a.a.
Protein Preferred Names Protein Names

cytoplasmic tyrosine-protein kinase BMX

  • BTK-like on X chromosome

  • Etk/Bmx cytosolic tyrosine kinase

  • NTK38 tyrosine kinase

  • bone marrow tyrosine kinase gene in chromosome X protein

  • epithelial and endothelial tyrosine kinase

BMX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
BMX P51813 PIM1 Homo sapiens P11309-2
Anti Bait CoIP
16186805
Intra
BMX P51813 PTPN21 Homo sapiens Q16825
Y2H Array
32296183
Intra
BMX P51813 PTPN21 Homo sapiens Q16825
Y2H Prey Pooling
32296183
Intra
BMX P51813 PTPN21 Homo sapiens Q16825
Validated Y2H
32296183
Intra
BMX P51813 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
BMX P51813 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
31980649
Intra
BMX P51813 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
BMX P51813 BIRC2 Homo sapiens Q13490
Validated Y2H
32296183
Intra
BMX P51813 BIRC2 Homo sapiens Q13490
Y2H Array
32296183
Intra
BMX P51813 BIRC2 Homo sapiens Q13490
Y2H Prey Pooling
32296183
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Array
25416956
Intra
BMX P51813 STAT3 Homo sapiens P40763
Validated Y2H
25416956
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Array
31515488
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Prey Pooling
32296183
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Prey Pooling
25416956
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Array
25814554
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Array
32296183
Intra
BMX P51813 PIM1 Homo sapiens P11309
Anti Bait CoIP
16186805
Cross: Cross-species interaction Intra: Intraspecies interaction

BMX Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P85063 ETK Antibody (YA4755) WB, ELISA Human

Related Diseases

Diseases Alias
Wet Beriberi
Agammaglobulinemia, X-Linked

  • X-Linked Agammaglobulinemia

  • XLA

  • Bruton Type Agammaglobulinemia

  • Bruton'S Agammaglobulinemia

  • Bruton-Type Agammaglobulinemia

  • Agmx1

  • Imd1

  • Agammaglobulinemia, X-Linked 1

  • Btk-Deficiency

  • Agammaglobulinemia

  • Hypogammaglobulinemia

  • Agammaglobulinemia, X-Linked, Type 1

  • Immunodeficiency 1

  • Bruton Agammaglobulinemia Tyrosine Kinase Deficiency

  • Bruton'S Agammaglobulinaemia

  • Bruton'S Sex-Linked Agammaglobulinemia

  • Bruton'S Type Agammaglobulinemia

  • Btk Deficiency

  • Agammaglobulinemia, Btk

  • Agammaglobulinemia, Bruton Tyrosine Kinase

  • Congenital Agammaglobulinemia

  • Immunodeficiency Type 1

  • X-Linked Agammaglobulinemia Type 1
Integrative Agnosia
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Thiamine Deficiency Disease
Beriberi

  • Thiamine Deficiency

  • Vitamin B1 Deficiency

  • Aneurin Deficiency

  • Thiamine Vitamin Deficiency

  • Beriberi Nos

  • Beriberi Due To Vitamin B1 Deficiency

  • Beriberi Due To Thiamine Vitamin Deficiency

  • Kakkè
Cardiomyopathy, Dilated, 1gg

  • Dilated Cardiomyopathy 1gg

  • CMD1GG

  • Cardiomyopathy, Dilated 1gg

  • Cardiomyopathy, Dilated, Type 1gg
Agammaglobulinemia

  • Hypogammaglobulinemia

  • Ighm

  • Mu Heavy Chain Deficiency

  • Mu-Heavy Chain Disease

  • Mu-Hcd

  • Mu-Chain Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit Effect
Pureté Phase
HY-176498 NBM-T-BMX-OS01 99.74% Phase 3
HY-130574 MnTE-2-PyP chloride / Phase 2
HY-139481 TL-895 Inhibitor 99.86% Phase 2
HY-111553 TAS0728 Inhibitor 99.71% Phase 1

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-80002 BMX-IN-1 Inhibitor 99.04% Unkown
HY-101267 CHMFL-BMX-078 Inhibitor 98.0% Unkown
HY-10644 Lck inhibitor 2 Inhibitor 99.73% Unkown
HY-183682 AZ14289671 Inhibitor / Unkown
HY-125662A BMX-001 Inhibitor / Unkown
HY-117900 PF-06250112 Inhibitor / Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-117900A (Rac)-PF-06250112 / Unkown
HY-148585 BTK-IN-22 Inhibitor / Unkown
HY-148594 BTK-IN-23 Inhibitor / Unkown
HY-173057 BMX-IN-3 / Unkown
HY-173280 Brefeldin A 4-O-nicotinate Inhibitor / Unkown
HY-174142 IHMT-15130 Inhibitor / Unkown
HY-182293 BTK-IN-48 Inhibitor / Unkown
HY-182902 IHMT-15137 / Unkown
HY-184005 IHMT-BMX-068 / Unkown
HY-184006 BMX ligand-1 Ligand / Unkown
HY-RS01557 BMX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01558 Bmx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01559 Bmx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BMX RGD RGD:1565643
Canis familiaris BMX VGNC VGNC:38489
Felis catus BMX VGNC VGNC:60140
Mus musculus BMX MGD MGI:1101778
Bos taurus BMX VGNC VGNC:26529
Macaca mulatta BMX VGNC VGNC:70269
Others BMX NCBI