TCAF1 - TRPM8 channel associated factor 1 Gene

Also Known as GATD9A; FAM115A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9747

Summary

Enables transmembrane transporter binding activity. Involved in negative regulation of cell migration; positive regulation of anion channel activity; and positive regulation of protein targeting to membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in placenta (RPKM 36.2), brain (RPKM 25.4) and 24 other tissues.

TCAF1 Products (3)

mRNA Protein Name
NM_001206938.2 NP_001193867.2 TRPM8 channel-associated factor 1 isoform 2
NM_001206941.2 NP_001193870.1 TRPM8 channel-associated factor 1 isoform 3
NM_014719.3 NP_055534.2 TRPM8 channel-associated factor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables transmembrane transporter binding IDA
IDA: Inferred from direct assay
25559186 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
25559186 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
25559186 GOA
involved in positive regulation of anion channel activity IDA
IDA: Inferred from direct assay
25559186 GOA
involved in positive regulation of protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
25559186 GOA
Cellular Component GO Annotation Evidence Références Source
located in plasma membrane IDA
IDA: Inferred from direct assay
25559186 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCAF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TCAF1 Q9Y4C2 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
Intra
TCAF1 Q9Y4C2 ZNF592 Homo sapiens Q92610
Y2H Array
25416956
Intra
TCAF1 Q9Y4C2 SF3B4 Homo sapiens Q15427
Y2H Pooling
16189514
Intra
TCAF1 Q9Y4C2 SF3B4 Homo sapiens Q15427
Validated Y2H
25416956
Intra
TCAF1 Q9Y4C2 SF3B4 Homo sapiens Q15427
Y2H Array
25416956
Intra
TCAF1 Q9Y4C2 ZNF24 Homo sapiens P17028
Validated Y2H
25416956
Intra
TCAF1 Q9Y4C2 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
Intra
TCAF1 Q9Y4C2 SPRY2 Homo sapiens O43597
Y2H Prey Pooling
25416956
Intra
TCAF1 Q9Y4C2 SPRY2 Homo sapiens O43597
Validated Y2H
25416956
Intra
TCAF1 Q9Y4C2 ZNF263 Homo sapiens O14978
Y2H Array
25416956
Intra
TCAF1 Q9Y4C2 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Intra
TCAF1 Q9Y4C2 IKZF3 Homo sapiens Q9UKT9
Y2H Array
31515488
Intra
TCAF1 Q9Y4C2 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
25416956
Intra
TCAF1 Q9Y4C2 TCF3 Homo sapiens P15923
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-12904 TCA1 Inhibitor 98.04% Unkown
HY-149934 DCAF1 binder 1 99.12% Unkown
HY-185391 DCAF1 ligand 2 99.89% Unkown
HY-156743 DCAF1 binder 2 / Unkown
HY-169152 DCAF1 ligand 1 / Unkown
HY-176467 TAF1 ligand 1 Ligand / Unkown
HY-RS03557 DCAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12474 SCAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14157 TAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14289 TCAF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14320 TCOF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14967 TRAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182974 DCAF1 binder 3 / Unkown
HY-RS17005 Taf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19244 Traf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20901 Dcaf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23448 Taf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25733 Traf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27418 Dcaf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown