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Cat. No.: HY-187115

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GGW

GGW is a tripeptide with neuroprotective activity. GGW blocks the mitochondria-mediated apoptosis pathway, reverses glutamate-induced upregulation of the pro-apoptotic protein Bax and downregulation of the anti-apoptotic protein Bcl-2. GGW reduces ROS production, reverses the depletion of SOD and Glutathione Peroxidase, decreases intracellular calcium concentration, and reverses the collapse of mitochondrial membrane potential. GGW can be used in studies related to memory impairment induced by sleep deprivation.

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CAS No.: 20762-32-7
Formule: C₁₅H₁₈N₄O₄
Masse moléculaire:318.33

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Please store the product under the recommended conditions in the Certificate of Analysis.

GGW Chemical Structure

CAS No.: 20762-32-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

Bax

Bcl-2

Voir tous les produits spécifiques à Isoform Bcl-2 Family :

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase :

GPX1
GPX4

In Vitro

Oxidative StressMitochondrial FunctionApoptosis

Oxidative Stress

GGW (0.10 mM; 24 h) protects PC12 cells from glutamate-induced cytotoxicity and restores cell viability to 78.29% of that in the control group^[1].
GGW (0.10 mM) exhibits free radical scavenging activity in cell-free ABTS assays^[1].

Oxidative Stress

Mitochondrial Function

GGW (0.10 mM; 24 h) reverses the glutamate-induced decreases in SOD and GSH-px activities and increase in MDA content in PC12 cells; it reduces ROS accumulation, inhibits LDH leakage, and alleviates cell damage; it suppresses Ca²⁺ influx and reduces intracellular calcium concentration to 250.65 mmol/L; it reverses mitochondrial membrane potential collapse and restores MMP to 90.17% of the control group level^[1].

Apoptosis

GGW (0.10 mM; 24 h) regulates the expression of apoptosis-related proteins Bax and Bcl-2 in glutamate-treated PC12 cells, reducing the Bax/Bcl-2 ratio to 107.04% of that in the control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

rat pheochromocytoma PC12 cells (glutamate-induced cytotoxicity)
Concentration:

0.10 mM
Incubation Time:

24 h
Result:

Restored PC12 cell viability to 78.29% of the control value.

Western Blot Analysis^[1]

Cell Line:

glutamate-injured PC12 cells
Concentration:

0.10 mM
Incubation Time:

24 h
Result:

Down-regulated Bax expression.
Up-regulated Bcl-2 expression.
Reduced the Bax/Bcl-2 ratio to 107.04% of the control value.

Related Protocols :

Chemical Information

CAS No. 20762-32-7
Masse moléculaire 318.33
Formule C₁₅H₁₈N₄O₄
SMILES

NCC(NCC(N[C@H](C(O)=O)CC1=CNC2=CC=CC=C12)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Wang S G, et al. Walnut (Juglans regia) Peptides Reverse Sleep Deprivation‑Induced Memory Impairment in Rat via Alleviating Oxidative Stress. Journal of Agricultural and Food Chemistry, 2018, 66(40): 10617‑10627.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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GGW

Voir tous les produits spécifiques à Isoform Bcl-2 Family

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase