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Cat. No.: HY-147850

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JMI-346

JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQ^S (3D7; IC₅₀=13 µM) and CQ^R (RKL-9; IC₅₀=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent.

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CAS No.: 2091841-46-0
Formule: C₁₉H₂₀N₄O₂
Masse moléculaire:336.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

JMI-346 Chemical Structure

CAS No.: 2091841-46-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

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Cellular Effect

Cell Line	Type	Value	Description	References
THP-1	IC₅₀	291.56 μM Compound: 40	Cytotoxicity against human PMA-differentaited THP1 cells after 24 hrs by MTT assay Cytotoxicity against human PMA-differentaited THP1 cells after 24 hrs by MTT assay	[PMID: 28359789]

Chemical Information

CAS No. 2091841-46-0
Masse moléculaire 336.39
Formule C₁₉H₂₀N₄O₂
SMILES

N[C@@H](CC1=CC=CC=C1)C(OCC2=CN(C3=CC=C(C)C=C3)N=N2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Uddin A, et al. Identification and structure-activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease. Bioorg Chem. 2020 Oct;103:104142. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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JMI-346

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JMI-346 Related Classifications

HY-147850 Related Classifications