KHK2805
KHK2805 (RA15-7) is a humanized antibody against folate receptor α (FOLR1), with a Kd of 0.647 nM for human FOLR1. KHK2805 binds to a unique epitope of FOLR1 and mediates antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against FOLR1-expressing cells. KHK2805 exhibits cytotoxicity against both ovarian cancer cells and Platinum (HY-W096169D)-resistant ovarian cancer cells. KHK2805 can be used for the research of tumors such as ovarian cancer.
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Human
KHK2805 (10 μg/mL; 1 h) binds strongly to the FOLR1-expressing human ovarian cancer cell lines IGROV1, OVMANA, SKOV3 and OVCAR3[1].
KHK2805 (0.1-10000 ng/mL; 2 h) induces complement-dependent cytotoxicity (CDC) against FOLR1-expressing human ovarian cancer cell lines IGROV1 and OVMANA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice (C.B-17/Icr-scid/scid Jcl, female, 6 weeks old, Platinum (HY-W096169D)-resistant peritoneal dissemination and malignant ascites model induced by intraperitoneal inoculation of IGROV1 cells)[1]
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Dosage:0.1 mg/kg; 1 mg/kg; 10 mg/kg
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Administration:i.v.; twice a week; once a week
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Result:Significantly reduced intraperitoneal tumor burden and eliminated detectable malignant ascites (10 mg/kg, twice a week).
Significantly reduced both intraperitoneal tumor burden and ascites volume (1 mg/kg, once a week).
Reduced tumor burden and ascites volume, with no statistically significant effects (0.1 mg/kg, once a week).
Significantly prolonged median survival.
FOLR1/FRA
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[KHK2805]
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Synonyms
RA15-7, HuRA15-7Acc
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KHK2805 Related Classifications
HY-P992004 Related Classifications
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