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Cat. No.: HY-129210

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KMUP-4

KMUP-4, as a xanthine derivative with cGMP-enhancing activity, induces aortic relaxation through endothelium-dependent and independent mechanisms. KMUP-4 increases cytoplasmic cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) levels by inhibiting phosphodiesterases (PDEs) and activating K⁺ channels. KMUP-4 can be used in the study of cardiovascular diseases.

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CAS No.: 864873-81-4
Formule: C₁₉H₂₃N₇O₄
Masse moléculaire:413.43

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

KMUP-4 Chemical Structure

CAS No.: 864873-81-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE) :

In Vitro

KMUP-4 (1 nM-100 μM) produces concentration-dependent vasorelaxant effects on deendothelial aortas (E2) (pEC₅₀=5.94) and intact endothelial aortas (E+) (PEC₅₀=6.45), indicating that the vasodilatory effect of KMUP-4 is partially dependent on endothelial cells^[1].
KMUP-4 (10 μM) shows 56%, 33% and 15% inhibitory activity against PDE3, PDE4 and PDE5 in HUVECs^[1].
KMUP-4 (0.1 μM, 18 h) increases significantly the expression of eNOS protein in HUVECs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 864873-81-4
Masse moléculaire 413.43
Formule C₁₉H₂₃N₇O₄
SMILES

O=C1C2=C(N(C(N1C)=O)C)N=CN2CCN3CCN(CC3)C4=C(C=CC=C4)[N+]([O-])=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. BN Wu, et al. Aortic Smooth Muscle Relaxants KMUP-3 and KMUP-4, Two Nitrophenylpiperazine Derivatives of Xanthine, Display cGMP-Enhancing Activity: Roles of Endothelium, Phosphodiesterase, and K:+: Channel. Journal of cardiovascular pharmacology 46.5 (2005): 600-608. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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