LCA-H10
LCA-H10 is a lithocholic acid-histidine decapeptide conjugate, a biocompatible lipid nanoparticle (LNP) additive that reduces ionizable lipid proportions, functions as an endosomal escape inducer, and enhances siRNA encapsulation. LCA-H10 increases hepatic accumulation of LNPs in mice after intravenous injection when incorporated into LiLNP-LH and reduces proinflammatory cytokines (IL-6, TNF, IL-1β) in mouse serum. LCA-H10 can be used for the research of prostate cancer.
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- Formule: C84H110N30O13
- Masse moléculaire:1747.97
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
LiLNP-LH (containing LCA-H10) (0-187.8 nM siRNA; 5 h + 43 h) provided enhanced gene silencing activity in PC3-GFP cells compared to LiLNP and LiLNP-H, with an IC50 of 216.9 nM[1].
LiLNP-LH (containing LCA-H10) (0.3 μg/mL siRNA (PC3); 1.5 μg/mL siRNA (HepG2); 5-6 h) showed comparable intracellular uptake to HiLNP in HepG2 cells and similar uptake to LiLNP in PC3 cells[1].
LiLNP-LH (containing LCA-H10) (0.9% molar ratio) achieved high siRNA encapsulation efficiency (83.7%) comparable to HiLNP despite a low ionizable lipid proportion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (6 weeks old, female)[1]
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Dosage:40 μg siRNA per mouse (biodistribution); 2 mg/kg siRNA (cytokine analysis)
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Administration:i.v.
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Result:Exhibited 4.6× 10¹⁰ total flux in the liver (1.6-fold higher than HiLNPs) and 50.4 × 10² RFI/mg organ in liver homogenates. Reduced serum IL-6 levels to 144.1 pg/mL (30.6-fold lower than HiLNPs), TNF levels by 29.9-fold, and IL-1β levels by 14.5-fold compared to HiLNPs.
Chemical Information
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Masse moléculaire 1747.97
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Formule C84H110N30O13
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Sequence
LCA-His-His-His-His-His-His-His-His-His-His
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Sequence Shortening
LCA-HHHHHHHHHH
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LCA-H10 Related Classifications
HY-P11614 Related Classifications
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