Ligufalimab
Based on 1 publication(s) in Google Scholar
Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity.
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- Pureté: 98.81%
- CAS No.: 2428381-55-7
- Masse moléculaire:144.58 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ligufalimab
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Activité biologique
Human IgG4 kappa
Human
CD47
Ligufalimab binds to human CD47 antigen with an EC50 value of 0.078 nM, KD value of 0.152 nM[1].
Ligufalimab (0-3000 nM) does not induce RBC hemagglutination[1].
Ligufalimab (0.1, 1, 10 µg/mL) induces phagocytosis of Raji, Jurkat and Ramos cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID/Beige mice (Raji xenograft model, MDA-MB-231 xenograft model)[1]
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Dosage:0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model
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Administration:I.v.
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Result:Inhibited tumor growth with the tumor inhibition rate of 88.56%, 63.78% at 1, 0.1 mg/kg.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa
ELISA, FACS, Functional assay
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Flow cytometric analysis of 106 Jurkat cells with Ligufalimab (HY-P99706, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor® 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.
Chemical Information
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CAS No. 2428381-55-7
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Appearance Liquid
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Masse moléculaire 144.58 kDa
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Color Colorless to light yellow
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SMILES
[Ligufalimab]
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Synonyms
AK 117
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Transfusion
Anti-CD47 drug interference in pre-transfusion testing can be overcome by antigen masking. [Abstract]2025 Aug 13. PMID: 40799186
Pureté et documentation
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Fiche technique (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ligufalimab Related Classifications
HY-P99706 Related Classifications
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