NaPi2b-IN-3
NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia.
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- CAS No.: 2227443-66-3
- Formule: C45H51N5O7
- Masse moléculaire:773.92
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Pharmacokinetic Parameters of NaPi2b-IN-3 in male Sprague-Dawley rats[1].
| IV (1 mg/kg) | PO (10 mg/kg) | |
| AUC0-t (h·ng/mL) | 834 ± 353 | 1090 ± 430 |
| Cmax (ng/mL) | 568 ± 261 | |
| F (%) | 13.1 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats[1]
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Dosage:1 and 10 mg/kg
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Administration:IV and PO; single dosage
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Result:Exhibited good activity and moderate hydrophobicity and systemically exposed to some extent.
Chemical Information
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CAS No. 2227443-66-3
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Masse moléculaire 773.92
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Formule C45H51N5O7
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SMILES
CCC(N(CC1=CC(C(NC2=C(C3=C(N2)C=CC=C3)C(NC4=CC=C(C=C4)CCCC5=CC=C(C=C5)C(O)=O)=O)=O)=CC=C1)CCN(C(CCC(O)=O)=O)C)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NaPi2b-IN-3 Related Classifications
HY-146429 Related Classifications
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