NIP 142
NIP-142 is a benzopyran derivative with multiple ion channel-blocking effects. NIP-142 selectively blocks the potassium ion channels enriched in atrial muscle, prolonging the effective refractory period (ERP) and action potential duration (APD) of the atrium, while having minimal effect on ventricular repolarization. NIP-142 also inhibits L-type/T-type calcium channels and sodium channels, further contributing to its anti-arrhythmic effect. NIP-142 shows significant efficacy in various atrial fibrillation models. NIP-142 can be used for research on arrhythmias.
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- CAS No.: 203002-58-8
- Formule: C23H27N3O6
- Masse moléculaire:441.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
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L-type calcium channel |
T-type calcium channel |
Chemical Information
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CAS No. 203002-58-8
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Masse moléculaire 441.48
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Formule C23H27N3O6
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SMILES
COC(C=C1)=CC=C1CC(NC2=C([N+]([O-])=O)C=C(OC(C)([C@@H]3O)C)C([C@@H]3NC4CC4)=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NIP 142 Related Classifications
HY-W705705 Related Classifications
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