NOS-IN-4
NOS-IN-4 (Compound 3) is a neuronal nitric oxide synthase (nNOS) inhibitor with an IC50 of 4.00 μM that inhibits nNOS activity. The combined use of alpha-lipoic acid and NOS-IN-4 has a protective effect against MPTP (HY-W114750)-induced dopamine depletion in the mouse brain. NOS-IN-4 can be used for the research of neurological disease.
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- CAS No.: 3737-39-1
- Formule: C11H10N2S
- Masse moléculaire:202.28
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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nNOS 4.00 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | Inhibition |
-6.99 %
Compound: LTA
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
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10.21203/rs.3.rs-23951/v1 |
NOS-IN-4 (up to 100 µM) is inactive in protecting mouse hippocampal neuronal HT22 cells from glutamate-induced cytotoxicity[1].
NOS-IN-4 (up to 100 µM) is inactive in preventing glutamate-induced glutathione depletion in mouse hippocampal neuronal HT22 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3737-39-1
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Masse moléculaire 202.28
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Formule C11H10N2S
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SMILES
N=C(NC=1C=CC=CC1)C=2SC=CC2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NOS-IN-4 Related Classifications
HY-W839206 Related Classifications
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