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Cat. No.: HY-108044R

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ONO-5334 (Standard)

ONO-5334 (Standard) is the analytical standard of ONO-5334 (HY-108044). This product is intended for research and analytical applications. ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with K_i values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC₅₀ value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 868273-90-9
Formule: C₂₁H₃₄N₄O₄S
Masse moléculaire:438.58

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ONO-5334 (Standard) Chemical Structure

CAS No.: 868273-90-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
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Activité biologique

Description

IC₅₀ & Target

Ki: 0.10 nM (human cathepsin K)
Ki: 0.049 nM (rabbit cathepsin K)
Ki: 0.85 nM (rat cathepsin K)^[1]

Voir tous les produits spécifiques à Isoform Cathepsin :

Chemical Information

CAS No. 868273-90-9
Masse moléculaire 438.58
Formule C₂₁H₃₄N₄O₄S
SMILES

O=C(C(N/N=C(SC[C@H]1C)/N1C)=O)[C@H](C2CCOCC2)NC(C3CCCCCC3)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Ochi Y, et al. Effects of ONO-5334, a novel orally-active inhibitor of cathepsin K, on bone metabolism. Bone. 2011 Dec;49(6):1351-6. [Content Brief]

[2]. Laura Riva, et al.A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. bioRxiv. 2020 Apr 17;2020.04.16.044016. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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ONO-5334 (Standard)

Voir tous les produits spécifiques à Isoform Cathepsin

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

ONO-5334 (Standard) Related Classifications

HY-108044R Related Classifications