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Cat. No.: HY-121723

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PU-H39

PU-H39 is a selective Grp94 inhibitor with an IC₅₀ of 0.12 μM. PU-H39 can be used for the research of breast cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 852030-38-7
Formule: C₁₆H₁₃Cl₂N₅S
Masse moléculaire:378.28

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Please store the product under the recommended conditions in the Certificate of Analysis.

PU-H39 Chemical Structure

CAS No.: 852030-38-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

PU-H39 is a selective Grp94 inhibitor with an IC₅₀ of 0.12 μM. PU-H39 can be used for the research of breast cancer^[1].

Voir tous les produits spécifiques à Isoform HSP :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-BR-3	IC₅₀	>500 μM Compound: 11l	Inhibitory concentration against SKBr3 cell line Inhibitory concentration against SKBr3 cell line	[PMID: 15828828]
SK-BR-3	IC₅₀	500 μM Compound: 11l	Inhibitory concentration against SKBr3 cell line Inhibitory concentration against SKBr3 cell line	[PMID: 15828828]

In Vitro

PU-H39 (compound 9g) shows minimal off-target binding to kinases at 10 μM, exhibiting 34% and 32% inhibition of MKNK2 and ROCK2 kinases respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 852030-38-7
Masse moléculaire 378.28
Formule C₁₆H₁₃Cl₂N₅S
SMILES

ClC1=CC=C(SC2=NC=3C(=NC=NC3N2CCCC#C)N)C(Cl)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Patel HJ, et al. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem. 2015;58(9):3922-3943. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- In Vitro
Chemical Information
Pureté et documentation
Références

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PU-H39

Voir tous les produits spécifiques à Isoform HSP

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PU-H39 Related Classifications

HY-121723 Related Classifications