RBI257
RBI257 is a selective dopamine D4R antagonist with a pKi of 8.42 for the hD4.4 receptor. RBI257 acts as a competitive antagonist at the hD4.4 receptor, blocking dopamine-stimulated G protein activation and GIRK current activation. RBI257 can be used for research on hypertension and schizophrenia.
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- CAS No.: 194038-94-3
- Formule: C21H28IN3O
- Masse moléculaire:465.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
Human D4 Receptor 8.42 (pKi) |
In Vitro
RBI257 exhibits high affinity for the hD4.4 receptor in CHO-hD4.4 cell membranes (pKi = 8.42)[3].
RBI257 acts as an antagonist of the hD4.4 receptor and exhibits potent antagonism of dopamine-stimulated [35S]GTPγS binding, with pKB values of 9.37 (30 mM NaCl) and 9.01 (100 mM NaCl)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 194038-94-3
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Masse moléculaire 465.38
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Formule C21H28IN3O
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SMILES
IC1=CC=C(C=C1)CN2CCC(N(C3=NC=CC=C3OC(C)C)C)CC2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RBI257 Related Classifications
HY-187840 Related Classifications
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