SB1578
SB1578 (CT-1578) is a selective JAK2 and FLT3 inhibitor with an IC50 of 46 nM and 60 nM, respectively. SB1578 exhibits high selectivity for other kinase targets. SB1578 can be used for the study of non-oncology indication rheumatoid arthritis.
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- CAS No.: 937273-04-6
- Formule: C26H30N4O4
- Masse moléculaire:462.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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JAK2 46 nM (IC50) |
FLT3 60 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SET-2 | IC50 |
0.246 nM
Compound: 14l, SB1578, 67:33 trans/Cis mixture
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Antiproliferative activity against human SET2 cells expressing JAK2 V617F mutan
Antiproliferative activity against human SET2 cells expressing JAK2 V617F mutan
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[PMID: 22339472] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 937273-04-6
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Masse moléculaire 462.54
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Formule C26H30N4O4
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SMILES
N1(CCCC1)CCOC2=CC=C3C=C2COC/C=C/COCC4=CC=C(O4)C5=CC=N/C(N5)=N/3
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Synonyms
CT-1578
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB1578 Related Classifications
HY-16449 Related Classifications
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