SCO-267
Based on 3 publication(s) in Google Scholar
SCO-267 is an allosteric GPR40 full agonist. SCO-267 can be used for the research of chronic diseases including diabetes.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.88%
- CAS No.: 1656261-09-4
- Formule: C36H46N4O5
- Masse moléculaire:614.77
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) SCO-267
More
Activité biologique
GPR40[1]
SCO-267 (CHO cells) activates the Gαq, Gαs, and Gα12/13 pathways and β-Arrestin Recruitment. SCO-267 is allosteric with fasiglifam and an endogenous ligand[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:N-STZ rats[1]
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Dosage:1 or 10 mg/kg
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Administration:P.o.;
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Result:Improved insulin sensitivity and exerted sustained glucose-lowering effect.
Chemical Information
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CAS No. 1656261-09-4
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Appearance Solid
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Masse moléculaire 614.77
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Formule C36H46N4O5
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Color Off-white to light yellow
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SMILES
CC(C)(C)CN(C1=CC=CC(C)=N1)C(C2=C(N3CCC(CC3)COC4=CC([C@H](C5CC5)CC(O)=O)=CC=N4)C=C(C=C2)OC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Biopharm Drug Dispos
2024 Feb;45(1):30-42. PMID: 38236698 -
Biomed Chromatogr
Preclinical pharmacokinetics and metabolism study of SCO-267, a GPR40 full agonist, in beagle dogs using ultra-high performance liquid chromatography coupled to tandem mass spectrometry. [Abstract]2023 Sep;37(9):e5685. PMID: 37189222 -
Rapid Commun Mass Spectrom
High-resolution accurate mass approach to characterization of SCO-267 metabolites using liquid chromatography hybrid quadrupole Orbitrap mass spectrometry. [Abstract]2022 Jul 30;36(14):e9325. PMID: 35560672
Solvant et solubilité
DMSO : 100 mg/mL (162.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.6266 mL | 8.1331 mL | 16.2662 mL | 40.6656 mL |
| 5 mM | 0.3253 mL | 1.6266 mL | 3.2532 mL | 8.1331 mL | |
| 10 mM | 0.1627 mL | 0.8133 mL | 1.6266 mL | 4.0666 mL | |
| 15 mM | 0.1084 mL | 0.5422 mL | 1.0844 mL | 2.7110 mL | |
| 20 mM | 0.0813 mL | 0.4067 mL | 0.8133 mL | 2.0333 mL | |
| 25 mM | 0.0651 mL | 0.3253 mL | 0.6506 mL | 1.6266 mL | |
| 30 mM | 0.0542 mL | 0.2711 mL | 0.5422 mL | 1.3555 mL | |
| 40 mM | 0.0407 mL | 0.2033 mL | 0.4067 mL | 1.0166 mL | |
| 50 mM | 0.0325 mL | 0.1627 mL | 0.3253 mL | 0.8133 mL | |
| 60 mM | 0.0271 mL | 0.1356 mL | 0.2711 mL | 0.6778 mL | |
| 80 mM | 0.0203 mL | 0.1017 mL | 0.2033 mL | 0.5083 mL | |
| 100 mM | 0.0163 mL | 0.0813 mL | 0.1627 mL | 0.4067 mL |
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