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Cat. No.: HY-130559

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SL-3-19

SL-3-19 is a tubulin ligand. SL-3-19 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-3-19 has a higher activity than SL-1-73 (HY-130558). SL-3-19 can be used for the research of ESCC and other tumors.

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CAS No.: 2000199-45-9
Formule: C₂₀H₁₉N₃O₅S
Masse moléculaire:413.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

SL-3-19 Chemical Structure

CAS No.: 2000199-45-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Bel-7402	IC₅₀	0.056 μM Compound: 13f	Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
Bel-7402	IC₅₀	0.056 μM Compound: 4b	Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay	[PMID: 32113125]
HepG2	IC₅₀	0.012 μM Compound: 13f	Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
HepG2	IC₅₀	0.012 μM Compound: 4b	Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay	[PMID: 32113125]
MCF7	IC₅₀	0.014 μM Compound: 13f	Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
MCF7	IC₅₀	0.014 μM Compound: 4b	Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay	[PMID: 32113125]
MIA PaCa-2	IC₅₀	0.051 μM Compound: 13f	Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]

Chemical Information

CAS No. 2000199-45-9
Masse moléculaire 413.45
Formule C₂₀H₁₉N₃O₅S
SMILES

O=S(NC1=CC=C(OC)N=C1OC)(C2=CC=C3C(C4=C(N3C)C=C(O)C=C4)=C2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Niu F, et al. Novel carbazole sulfonamide microtubule-destabilizing agents exert potent antitumor activity against esophageal squamous cell carcinoma. Cancer Lett. 2018 Apr 28;420:60-71. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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