SLB1122168
Based on 1 publication(s) in Google Scholar
SLB1122168 is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC50 of 94 nM. SLB1122168 induces lymphopenia in circulating lymphocytes in mice and rats.
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- CAS No.: 2999629-17-1
- Formule: C22H36ClN3O
- Masse moléculaire:393.99
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Activité biologique
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S1P |
SLB1122168 (Compound 33p) (0.3 μM; 18-20 h) potently inhibits Spns2-mediated S1P release in mouse Spns2-transfected HeLa cells with an IC50 of 94 nM[1].
SLB1122168 (10 μM) shows no inhibitory activity against Mfsd2b-mediated S1P release from mouse red blood cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SLB1122168 (10 mg/kg; i.p.; single dose) induces a 55% decrease in circulating lymphocytes in male Sprague-Dawley rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (female)[1]
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Dosage:10 mg/kg; 30 mg/kg
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Administration:i.p.; single dose
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Result:Induced a significant decrease in circulating lymphocytes relative to vehicle control at 4 h post-dose.
Caused no significant change in plasma S1P levels at 4 h post-dose.
Induced a dose-dependent decrease in circulating lymphocytes relative to vehicle control at 16 h post-dose.
Chemical Information
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CAS No. 2999629-17-1
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Masse moléculaire 393.99
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Formule C22H36ClN3O
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SMILES
CCCCCCCCCCC1=CC=C2C(OC(NC[C@@H]3CNCC3)=N2)=C1.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
A Spinster-like Transporter at the Inner Membrane Complex is critical for Toxoplasma gondii cytokinesis, motility and invasion. [Abstract]2026 Jan 28;22(1):e1013886. PMID: 41604433
Pureté et documentation
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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