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Cat. No.: HY-155294

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SM-122

SM-122 is a monovalent Smac mimetic targeting cellular inhibitor of apoptosis protein (cIAP)-1/2. SM-122 can induce cIAP-1/2 degradation and weakly induce apoptosis in tumor cells. SM-122 can be used for the research of cancer, such as breast cancer.

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CAS No.: 874270-38-9
Formule: C₂₈H₃₆N₄O₃
Masse moléculaire:476.61

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SM-122 Chemical Structure

CAS No.: 874270-38-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

cIAP-1

cIAP-2

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Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	1400 nM Compound: 18; SM-122	Cytotoxicity against human HL60 cells assessed as reduction in cell viability Cytotoxicity against human HL60 cells assessed as reduction in cell viability	[PMID: 30676015]
MDA-MB-231	EC₅₀	1.03 μM Compound: 1, SM-122	Reversal of human XIAP BIR3-mediated suppression of cytochrome c-induced caspase-3/-7 activity in human MDA-MB-231 cell lysate after 30 mins by cell free functional assay Reversal of human XIAP BIR3-mediated suppression of cytochrome c-induced caspase-3/-7 activity in human MDA-MB-231 cell lysate after 30 mins by cell free functional assay	[PMID: 19049347]
MDA-MB-231	IC₅₀	259 nM Compound: 1, SM-122	Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay	[PMID: 19049347]
MDA-MB-231	IC₅₀	259 nM Compound: 7, SM-122	Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay	[PMID: 19138149]
MDA-MB-231	IC₅₀	410 nM Compound: 20	Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay	[PMID: 18954041]
MDA-MB-231	IC₅₀	633 nM Compound: 15, SM-125	Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay	[PMID: 21462933]
SK-OV-3	IC₅₀	900 nM Compound: 20	Growth inhibition of human SKOV3 cells after 4 days by WST8 assay Growth inhibition of human SKOV3 cells after 4 days by WST8 assay	[PMID: 18954041]

Chemical Information

CAS No. 874270-38-9
Masse moléculaire 476.61
Formule C₂₈H₃₆N₄O₃
SMILES

O=C([C@H]1N2[C@](CCCC[C@@H](C2=O)NC([C@H](C)NC)=O)([H])CC1)NC(C3=CC=CC=C3)C4=CC=CC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lu J, et al. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res. 2008 Nov 15;68(22):9384-93. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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SM-122

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