Suberogorgin
Suberogorgin is a selective and reversible Acetylcholinesterase inhibitor. It is found in the Gorgoniae suberogorgia species from the South China Sea. Suberogorgin improves memory capacity in mice and reverses memory retention impairment induced by Cycloheximide (HY-12320) or Scopolamine (HY-N0296). It reduces urine output in rats and anesthetized cats. Suberogorgin increases respiratory rate, tidal volume, and minute ventilation in anesthetized cats, and exerts no significant effect on in vivo blood pressure in anesthetized cats. Suberogorgin is used in research related to memory disorders.
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- CAS No.: 110043-85-1
- Formule: C15H20O3
- Masse moléculaire:248.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Description
IC50 & Target
[1]|
AChE |
In Vivo
Suberogorgin (1.9 mg/kg; i.p.) improves memory performance in 14 month old aged mice[2].
Suberogorgin (1.3-1.9 mg/kg; i.p.) reverses pharmacologically induced memory retention impairment in mice[2].
Suberogorgin (0.4 mg/kg; i.v.) causes 63% urine volume reduction, stimulates respiration, and does not alter blood pressure in anesthetized cats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (3-4 month old, aging)[2]
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Dosage:1.9 mg/kg; 2.9 mg/kg; 4.3 mg/kg
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Administration:i.p.
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Result:Lengthened step-down latency by 195% at 1.9 mg/kg.
Shortened escape latency by 56% at 1.9 mg/kg.
Inhibited brain AChE activity by 17% at 1.9 mg/kg.
Showed dose-dependent reduction in memory-improving and AChE inhibitory effects at 2.9 mg/kg and 4.3 mg/kg.
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Animal Model:Mice (14 month old, aged)[2]
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Dosage:1.9 mg/kg
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Administration:i.p.
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Result:Lengthened step-down latency by 187%.
Shortened escape latency by 52%.
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Animal Model:Mice[2]
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Dosage:1.3 mg/kg; 1.9 mg/kg
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Administration:i.p.
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Result:Reversed cycloheximide- or scopolamine-induced disruptions of memory retention at 1.3 mg/kg and 1.9 mg/kg.
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Animal Model:Cats (male, weighing 3.5 kg)[3]
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Dosage:0.4 mg/kg
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Administration:i.v.
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Result:Decreased urine volume by 63% with the effect lasting at least 9 h.
Increased respiratory rate by 19%.
Increased tidal volume by 26%.
Increased minute ventilation by 40%.
Showed no significant change in blood pressure within the 3 h observation period, with baseline (0 min) blood pressure of 14.2 kPa and 13.5 kPa at 180 min.
Chemical Information
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CAS No. 110043-85-1
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Masse moléculaire 248.32
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Formule C15H20O3
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SMILES
O=C(C1=C[C@]2(C)CC[C@]3([H])[C@]2(C(C[C@H]3C)=O)[C@@H]1C)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Suberogorgin Related Classifications
HY-187600 Related Classifications
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