SW155246
Based on 1 Customer Validation
SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC50s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.04%
- CAS No.: 420092-79-1
- Formule: C16H11ClN2O5S
- Masse moléculaire:378.79
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
12 μM
Compound: 19, SW55246
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Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintil
Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintil
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[PMID: 25406944] |
| Sf9 | IC50 |
38 μM
Compound: 19, SW55246
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Inhibition of His6-tagged human recombinant DNMT3a expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scinti
Inhibition of His6-tagged human recombinant DNMT3a expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scinti
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[PMID: 25406944] |
Chemical Information
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CAS No. 420092-79-1
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Appearance Solid
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Masse moléculaire 378.79
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Formule C16H11ClN2O5S
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Color Light brown to brown
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SMILES
ClC1=CC=C(C=C1[N+]([O-])=O)S(NC2=CC=C(C3=C2C=CC=C3)O)(=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 250 mg/mL (660.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Jessica A Kilgore, et al. Identification of DNMT1 selective antagonists using a novel scintillation proximity assay. J Biol Chem. 2013 Jul 5;288(27):19673-84. [Content Brief]
[2]. José L Medina-Franco, et al. Rationalization of activity cliffs of a sulfonamide inhibitor of DNA methyltransferases with induced-fit docking. Int J Mol Sci. 2014 Feb 21;15(2):3253-61. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6400 mL | 13.1999 mL | 26.3999 mL | 65.9996 mL |
| 5 mM | 0.5280 mL | 2.6400 mL | 5.2800 mL | 13.1999 mL | |
| 10 mM | 0.2640 mL | 1.3200 mL | 2.6400 mL | 6.6000 mL | |
| 15 mM | 0.1760 mL | 0.8800 mL | 1.7600 mL | 4.4000 mL | |
| 20 mM | 0.1320 mL | 0.6600 mL | 1.3200 mL | 3.3000 mL | |
| 25 mM | 0.1056 mL | 0.5280 mL | 1.0560 mL | 2.6400 mL | |
| 30 mM | 0.0880 mL | 0.4400 mL | 0.8800 mL | 2.2000 mL | |
| 40 mM | 0.0660 mL | 0.3300 mL | 0.6600 mL | 1.6500 mL | |
| 50 mM | 0.0528 mL | 0.2640 mL | 0.5280 mL | 1.3200 mL | |
| 60 mM | 0.0440 mL | 0.2200 mL | 0.4400 mL | 1.1000 mL | |
| 80 mM | 0.0330 mL | 0.1650 mL | 0.3300 mL | 0.8250 mL | |
| 100 mM | 0.0264 mL | 0.1320 mL | 0.2640 mL | 0.6600 mL |
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