TAK-137
TAK-137 is an AMPA receptor potentiator with weak agonistic effect. TAK-137 binds to the AMPA receptor ligand binding domain in a glutamate-dependent manner. TAK-137 potentiates AMPA-induced currents and Ca2+ influx. TAK-137 can be used for the research of neurological disease.
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- CAS No.: 1358749-55-9
- Formule: C19H16N2O3S
- Masse moléculaire:352.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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AMPA Receptor |
TAK-137 (30 μM; 60 min) potentiates AMPA-induced Ca2+ influx in rat primary hippocampal neurons with an EC50 of 0.42 μM and exhibits a 7.6% agonistic effect at 30 μM in the absence of AMPA[1].
TAK-137 (30 μM) potentiates AMPA-induced currents in rat primary hippocampal neurons with an EC50 of 1.4 μM and exhibits a 6.4% agonistic effect at 30 μM in the absence of AMPA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1358749-55-9
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Masse moléculaire 352.41
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Formule C19H16N2O3S
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SMILES
O=S1(=O)N=C2C(=CC=CN2CC1)C=3C=CC(OC=4C=CC=CC4)=CC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TAK-137 Related Classifications
HY-204388 Related Classifications
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