Tauromustine
Tauromustine is an orally active nitrosourea anticancer agent. Tauromustine has an alkylation effect and can damage the DNA function. Tauromustine has a high therapeutic index, especially in the study of Walker 256 rat sarcoma. It is also active against melanoma, breast cancer, pleural mesothelioma and ovarian cancer. Tauromustine is mainly metabolized in the liver, but some of its metabolites also have cytotoxicity.
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- CAS No.: 85977-49-7
- Formule: C7H15ClN4O4S
- Masse moléculaire:286.74
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Chemical Information
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CAS No. 85977-49-7
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Masse moléculaire 286.74
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Formule C7H15ClN4O4S
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SMILES
O=NN(CCCl)C(NCCS(=O)(N(C)C)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Gregor A, et al. Phase II study of tauromustine in malignant glioma. Eur J Cancer. 1992;28A(12):1959-62. [Content Brief]
[2]. Smyth JF, et al. Two phase III trials of tauromustine (TCNU) in advanced colorectal cancer. Ann Oncol. 1995 Nov;6(9):948-9. [Content Brief]
[3]. Bibby MC, et al. Influence of hydralazine on the pharmacokinetics of tauromustine (TCNU) in mice. Br J Cancer. 1992 Mar;65(3):347-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tauromustine Related Classifications
HY-119916 Related Classifications
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