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Cat. No.: HY-101040A

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Telacebec ditosylate

(Synonyms: Q203 ditosylate; IAP6 ditosylate)

7 Cited Publications

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Based on 7 publication(s) in Google Scholar

Telacebec ditosylate is a midazopyridine amide compound. Telacebec ditosylate is active against Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 2.7 nM in culture broth medium.

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CAS No.: 1566517-83-6
Formule: C₄₃H₄₄ClF₃N₄O₈S₂
Masse moléculaire:901.41

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Telacebec ditosylate Chemical Structure

CAS No.: 1566517-83-6

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Fluorescent Dye

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Activité biologique

Description

Telacebec ditosylate is a midazopyridine amide compound. Telacebec ditosylate is active against Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 2.7 nM in culture broth medium.

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Chemical Information

CAS No. 1566517-83-6
Masse moléculaire 901.41
Formule C₄₃H₄₄ClF₃N₄O₈S₂
SMILES

O=C(NCC1=CC=C(C=C1)N2CCC(CC2)C3=CC=C(C=C3)OC(F)(F)F)C4=C(N=C5C=CC(Cl)=CN54)CC.O=S(C6=CC=C(C=C6)C)(O)=O.O=S(C7=CC=C(C=C7)C)(O)=O
Synonyms

Q203 ditosylate; IAP6 ditosylate
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (7)

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Eur J Med Chem

Design, synthesis and biological evaluation of (Quinazoline 4-yloxy)acetamide and (4-oxoquinazoline-3(4H)-yl)acetamide derivatives as inhibitors of Mycobacterium tuberculosis bd oxidase. [Abstract]

2022 Nov 15:242:114639. PMID: 35973312
Int J Mol Sci

Response of Mycobacterium smegmatis to the Cytochrome bcc Inhibitor Q203. [Abstract]

2022 Sep 7;23(18):10331. PMID: 36142240

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

M. smegmatis wild-type (WT) and M. smegmatis mutant strain with knocked-out cytochrome bd (bd-KO) in the presence and absence of indicated Q203 (Telacebec, 0-10 μM, 0-80 h) concentrations.

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

The outgrowth of M. smegmatis bd-KO in presence of Q203 is not due to selection of mutant harboring compensatory mutations. After eventual growth resumption in presence of Q203 (Telacebec) at ~40 h (green curve), the bacteria were re-treated with Q203 (Telacebec) by diluting into fresh 7H9 complete medium containing the drug (blue curve) or re-grown in drug-free 7H9 complete medium for 16 h, and subsequently again diluted into fresh 7H9 complete medium containing the drug.

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Quantification of surviving M. smegmatis bd-KO after exposure to Q203 (Telacebec, 10 μM, 0-48 h) in 7H9 complete medium for the indicated time. Colony forming units (CFU/mL) were subsequently counted on agar plates after three days of incubation at 37 °C. Data are Mean ± SD from two independent experiments (biological replicates), each comprising three technical replicates.

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Representative dilution series of M. smegmatis bd-KO after exposure to Q203 (Telacebec) in 7H9 complete medium for the indicated time. Each spot represents a 5 µL aliquot.
ACS Infect Dis

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis. [Abstract]

2021 Jan 8;7(1):141-152. PMID: 33319550
Antimicrob Agents Chemother

Nitric Oxide-Dependent Electron Transport Chain Inhibition by the Cytochrome bc1 Inhibitor and Pretomanid Combination Kills Mycobacterium tuberculosis. [Abstract]

2021 Aug 17;65(9):e0095621. PMID: 34152815
Microbiol Spectr

GaMF1.39's antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876. [Abstract]

2023 Dec 12;11(6):e0228223. PMID: 37982630
bioRxiv

2024 June 11.
Elife

Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. [Abstract]

2021 Nov 25;10:e69418. PMID: 34819223

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Elife. 2021 Nov 25;10:e69418. [Abstract]

Rate of O₂ reduction by the hybrid supercomplex before and after addition of Q203(Telacebec).

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pethe K, et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med. 2013 Sep;19(9):1157-60. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Telacebec ditosylate

7 Cited Publications

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Activité biologique
- Description
Chemical Information
Publications (7)
Pureté et documentation
Références

1/16
1/16

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Customer Validation
M. smegmatis wild-type (WT) and M. smegmatis mutant strain with knocked-out cytochrome bd (bd-KO) in the presence and absence of indicated Q203 (Telacebec, 0-10 μM, 0-80 h) concentrations.
1/16

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Customer Validation
The outgrowth of M. smegmatis bd-KO in presence of Q203 is not due to selection of mutant harboring compensatory mutations. After eventual growth resumption in presence of Q203 (Telacebec) at ~40 h (green curve), the bacteria were re-treated with Q203 (Telacebec) by diluting into fresh 7H9 complete medium containing the drug (blue curve) or re-grown in drug-free 7H9 complete medium for 16 h, and subsequently again diluted into fresh 7H9 complete medium containing the drug.
1/16

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Customer Validation
Quantification of surviving M. smegmatis bd-KO after exposure to Q203 (Telacebec, 10 μM, 0-48 h) in 7H9 complete medium for the indicated time. Colony forming units (CFU/mL) were subsequently counted on agar plates after three days of incubation at 37 °C. Data are Mean ± SD from two independent experiments (biological replicates), each comprising three technical replicates.
1/16

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Sep 7;23(18):10331. [Abstract]

Customer Validation
Representative dilution series of M. smegmatis bd-KO after exposure to Q203 (Telacebec) in 7H9 complete medium for the indicated time. Each spot represents a 5 µL aliquot.
1/16

Telacebec ditosylate purchased from MedChemExpress. Usage Cited in: Elife. 2021 Nov 25;10:e69418. [Abstract]

Customer Validation
Rate of O₂ reduction by the hybrid supercomplex before and after addition of Q203(Telacebec).

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Telacebec ditosylate

Publications Citing Use of MedChemExpress (MCE) Telacebec ditosylate

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Chemical Information

Publications (7)

Pureté et documentation

Références

Calculators

Help & FAQs

Telacebec ditosylate Related Classifications

HY-101040A Related Classifications