Tropicamide-d3
Based on 1 Customer Validation
Tropicamide-d3 is the deuterium labeled Tropicamide. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops.
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- Pureté : 99.10%
- CAS No.: 2673270-13-6
- Formule: C17H17D3N2O2
- Masse moléculaire:287.37
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2673270-13-6
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Unlabeled CAS 1508-75-4
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Appearance Solid
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Masse moléculaire 287.37
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Formule C17H17D3N2O2
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Color White to off-white
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SMILES
[2H]C([2H])([2H])CN(CC1=CC=NC=C1)C(C(C2=CC=CC=C2)CO)=O
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Synonyms
Ro 1-7683-d3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : ≥ 30 mg/mL (104.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : ≥ 30 mg/mL (104.40 mM)
DMF : ≥ 30 mg/mL (104.40 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15. [Content Brief]
[3]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol / DMF | 1 mM | 3.4798 mL | 17.3992 mL | 34.7983 mL | 86.9959 mL |
| 5 mM | 0.6960 mL | 3.4798 mL | 6.9597 mL | 17.3992 mL | |
| 10 mM | 0.3480 mL | 1.7399 mL | 3.4798 mL | 8.6996 mL | |
| 15 mM | 0.2320 mL | 1.1599 mL | 2.3199 mL | 5.7997 mL | |
| 20 mM | 0.1740 mL | 0.8700 mL | 1.7399 mL | 4.3498 mL | |
| 25 mM | 0.1392 mL | 0.6960 mL | 1.3919 mL | 3.4798 mL | |
| 30 mM | 0.1160 mL | 0.5800 mL | 1.1599 mL | 2.8999 mL | |
| 40 mM | 0.0870 mL | 0.4350 mL | 0.8700 mL | 2.1749 mL | |
| 50 mM | 0.0696 mL | 0.3480 mL | 0.6960 mL | 1.7399 mL | |
| 60 mM | 0.0580 mL | 0.2900 mL | 0.5800 mL | 1.4499 mL | |
| 80 mM | 0.0435 mL | 0.2175 mL | 0.4350 mL | 1.0874 mL | |
| 100 mM | 0.0348 mL | 0.1740 mL | 0.3480 mL | 0.8700 mL |
Tropicamide-d3 Related Classifications
HY-B0321S Related Classifications
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