U-99363E
U-99363E is a selective dopamine D4 receptor antagonist with a Ki value of 2.2 nM. U-99363E exhibits at least 100-fold lower affinity for other dopaminergic, serotonergic and adrenergic receptors. U-99363E can be used in studies related to selective dopamine D4 site labeling or blockade.
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- CAS No.: 170856-57-2
- Formule: C20H27N3O
- Masse moléculaire:325.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
Human D4 Receptor 2.2 nM (Ki) |
In Vitro
U-99363E (1 μM; 16-18 h) antagonizes Quinpirole (HY-B1752)-induced mitogenesis in Chinese hamster ovary cells expressing the human dopamine D4 receptor[1].
U-99363E (1 μM; 1 h) binds with high affinity (Ki = 2.2 nM) and 126-fold selectivity to human dopamine D4 receptors (expressed in human embryonic kidney cell membranes) over rat D2i dopamine receptors, and exhibits at least 100-fold lower affinity for other tested dopaminergic, serotonergic, and adrenergic receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 170856-57-2
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Masse moléculaire 325.45
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Formule C20H27N3O
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SMILES
CCOC1=CC=CN=C1N(C2CCN(CC2)CC3=CC=CC=C3)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
U-99363E Related Classifications
HY-169136 Related Classifications
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