USP5-IN-1
Based on 3 publication(s) in Google Scholar
USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.
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- Pureté : 99.73%
- CAS No.: 2851040-81-6
- Formule: C19H20ClN3O5S
- Masse moléculaire:437.90
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) USP5-IN-1
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Activité biologique
Description
IC50 & Target
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USP5 |
In Vitro
USP5-IN-1 (2.8 μM) has a dissociation constant of 2.8 μM for USP5 ZnF-UBD and shows ≥30-fold selectivity over 9 homologous ZnF-UBD proteins[1].
USP5-IN-1 (0.8-26 μM) inhibits USP5 cleavage of Lys48-linked diubiquitin substrates in vitro in a dose-dependent manner with IC50 of 0.8 μM (DU48-03 substrate) and 26 μM (DU48-02 substrate)[1].
USP5-IN-1 (7-46 μM) displaces N-terminally fluorescently labeled ubiquitin from USP5 ZnF-UBD and full-length USP5 in a dose-dependent manner with IC50 of 7 μM and 46 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2851040-81-6
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Appearance Solid
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Masse moléculaire 437.90
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Formule C19H20ClN3O5S
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Color White to light yellow
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SMILES
O=S(C1=CC=C(C(NCC(O)=O)=O)N=C1)(N2CCC(C3=CC=C(Cl)C=C3)CC2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
USP5 inhibition via bone marrow-targeted engineered exosomes for myeloproliferative neoplasms therapy. [Abstract]2025 Jul 11;23(1):501. PMID: 40646529 -
Sci Adv
The cohesin-associated protein Pds5A governs the meiotic spindle assembly via deubiquitination of Kif5B in oocytes. [Abstract]2025 Apr 11;11(15):eadt6159. PMID: 40215310 -
Cell Mol Life Sci
P62 promotes FSH-induced antral follicle formation by directing degradation of ubiquitinated WT1. [Abstract]2024 May 20;81(1):221. PMID: 38763964
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (285.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.2836 mL | 11.4181 mL | 22.8363 mL | 57.0907 mL |
| 5 mM | 0.4567 mL | 2.2836 mL | 4.5673 mL | 11.4181 mL | |
| 10 mM | 0.2284 mL | 1.1418 mL | 2.2836 mL | 5.7091 mL | |
| 15 mM | 0.1522 mL | 0.7612 mL | 1.5224 mL | 3.8060 mL | |
| 20 mM | 0.1142 mL | 0.5709 mL | 1.1418 mL | 2.8545 mL | |
| 25 mM | 0.0913 mL | 0.4567 mL | 0.9135 mL | 2.2836 mL | |
| 30 mM | 0.0761 mL | 0.3806 mL | 0.7612 mL | 1.9030 mL | |
| 40 mM | 0.0571 mL | 0.2855 mL | 0.5709 mL | 1.4273 mL | |
| 50 mM | 0.0457 mL | 0.2284 mL | 0.4567 mL | 1.1418 mL | |
| 60 mM | 0.0381 mL | 0.1903 mL | 0.3806 mL | 0.9515 mL | |
| 80 mM | 0.0285 mL | 0.1427 mL | 0.2855 mL | 0.7136 mL | |
| 100 mM | 0.0228 mL | 0.1142 mL | 0.2284 mL | 0.5709 mL |
USP5-IN-1 Related Classifications
HY-139979 Related Classifications
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