UU-T02
Based on 1 publication(s) in Google Scholar
UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells.
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- Pureté: 99.94%
- CAS No.: 1500080-17-0
- Formule: C33H33ClN4O9
- Masse moléculaire:665.09
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) UU-T02
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Activité biologique
Ki: 1.36 μM (β-catenin/Tcf PPI)[1].
IC50: 6.3 μM (β-catenin/Tcf4), 680 μM (β-catenin/E-cadherin) , 210 μM (β-catenin/APC-R3)[2].
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Cell Line
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Type | Value | Description | References |
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| SW480 | IC50 |
231.9 μM
Compound: 42; UU-T02
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Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth by MTS assay
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth by MTS assay
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[PMID: 36183504] |
UU-T02 displays Ki values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively[2].
UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC50 of 6.3, 680, 210 μM，respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1500080-17-0
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Appearance Solid
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Masse moléculaire 665.09
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Formule C33H33ClN4O9
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Color Off-white to light yellow
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SMILES
OC(CC[C@@H](C(OC)=O)NC([C@H](CC(O)=O)NC([C@H](CC1=CC2=C(C=CC=C2)C=C1)NC(CC3=CC4=CC(Cl)=CC=C4N3)=O)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
2023 Apr 4;24(7):6733. PMID: 37047705
Solvant et solubilité
DMSO : 125 mg/mL (187.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS Chem Biol. 2014;9(1):193-201. [Content Brief]
[2]. Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58(11):4678-4692. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5036 mL | 7.5178 mL | 15.0356 mL | 37.5889 mL |
| 5 mM | 0.3007 mL | 1.5036 mL | 3.0071 mL | 7.5178 mL | |
| 10 mM | 0.1504 mL | 0.7518 mL | 1.5036 mL | 3.7589 mL | |
| 15 mM | 0.1002 mL | 0.5012 mL | 1.0024 mL | 2.5059 mL | |
| 20 mM | 0.0752 mL | 0.3759 mL | 0.7518 mL | 1.8794 mL | |
| 25 mM | 0.0601 mL | 0.3007 mL | 0.6014 mL | 1.5036 mL | |
| 30 mM | 0.0501 mL | 0.2506 mL | 0.5012 mL | 1.2530 mL | |
| 40 mM | 0.0376 mL | 0.1879 mL | 0.3759 mL | 0.9397 mL | |
| 50 mM | 0.0301 mL | 0.1504 mL | 0.3007 mL | 0.7518 mL | |
| 60 mM | 0.0251 mL | 0.1253 mL | 0.2506 mL | 0.6265 mL | |
| 80 mM | 0.0188 mL | 0.0940 mL | 0.1879 mL | 0.4699 mL | |
| 100 mM | 0.0150 mL | 0.0752 mL | 0.1504 mL | 0.3759 mL |
UU-T02 Related Classifications
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